Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease
The traditional management of Crohn's disease, which is based on progressive, step-wise treatment intensification with re-evaluation of response according to symptoms, does not improve long-term outcomes of Crohn's disease and places patients at risk for bowel damage. The introduction of n...
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| Veröffentlicht in: | Clinical gastroenterology and hepatology 2015-06, Vol.13 (6), p.1042-1050.e2 |
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| container_title | Clinical gastroenterology and hepatology |
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| creator | Bouguen, Guillaume Levesque, Barrett G Feagan, Brian G Kavanaugh, Arthur Peyrin–Biroulet, Laurent Colombel, Jean–Frederic Hanauer, Stephen B Sandborn, William J |
| description | The traditional management of Crohn's disease, which is based on progressive, step-wise treatment intensification with re-evaluation of response according to symptoms, does not improve long-term outcomes of Crohn's disease and places patients at risk for bowel damage. The introduction of novel therapies and the development of new approaches to treatment in rheumatoid arthritis led to better outcomes for patients. Prominent among these is a “treat to target” strategy that is based on regular assessment of disease activity by using objective clinical and biological outcome measures and the subsequent adjustment of treatments. This approach is complementary to the concept of early intervention in high-risk patients. This review evaluates current literature on this topic and proposes a definition for the concept of treating to targets for Crohn's disease. |
| doi_str_mv | 10.1016/j.cgh.2013.09.006 |
| format | Article |
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The introduction of novel therapies and the development of new approaches to treatment in rheumatoid arthritis led to better outcomes for patients. Prominent among these is a “treat to target” strategy that is based on regular assessment of disease activity by using objective clinical and biological outcome measures and the subsequent adjustment of treatments. This approach is complementary to the concept of early intervention in high-risk patients. 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All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-eff422eda83ba1166d7d4942a5e16c51a4dd8a321e32879b530dbf5fa232b6993</citedby><cites>FETCH-LOGICAL-c621t-eff422eda83ba1166d7d4942a5e16c51a4dd8a321e32879b530dbf5fa232b6993</cites><orcidid>0000-0003-2536-6618</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1542356513013013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24036054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-rennes.hal.science/hal-00878688$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouguen, Guillaume</creatorcontrib><creatorcontrib>Levesque, Barrett G</creatorcontrib><creatorcontrib>Feagan, Brian G</creatorcontrib><creatorcontrib>Kavanaugh, Arthur</creatorcontrib><creatorcontrib>Peyrin–Biroulet, Laurent</creatorcontrib><creatorcontrib>Colombel, Jean–Frederic</creatorcontrib><creatorcontrib>Hanauer, Stephen B</creatorcontrib><creatorcontrib>Sandborn, William J</creatorcontrib><title>Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease</title><title>Clinical gastroenterology and hepatology</title><addtitle>Clin Gastroenterol Hepatol</addtitle><description>The traditional management of Crohn's disease, which is based on progressive, step-wise treatment intensification with re-evaluation of response according to symptoms, does not improve long-term outcomes of Crohn's disease and places patients at risk for bowel damage. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Crohn Disease - drug therapy Crohn's Disease Drug Monitoring - methods Gastroenterology and Hepatology Human health and pathology Humans Hépatology and Gastroenterology Immunologic Factors - therapeutic use Intestinal Mucosa - pathology Life Sciences Mucosal Healing Prevention and Control Secondary Prevention - methods Therapy Treat to Target |
| title | Treat to Target: A Proposed New Paradigm for the Management of Crohn's Disease |
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