Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment

Rationale Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are increasingly used for the treatment of depression in children. Limited data are, however, available on their effects on brain development and their efficacy remains debated. Moreover, previous experimental studies are s...

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Veröffentlicht in:	Psychopharmacologia 2012-05, Vol.221 (2), p.329-339
Hauptverfasser:	Bouet, Valentine, Klomp, Anne, Freret, Thomas, Wylezinska-Arridge, Marzena, Lopez-Tremoleda, Jordi, Dauphin, François, Boulouard, Michel, Booij, Jan, Gsell, Willy, Reneman, Liesbeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescence Age Age Factors Animals Anxiety Behavior, Animal - drug effects Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain Cerebral Cortex - metabolism Children Cognitive science Cortex Data processing Depression Depression, Mental Development Drug therapy Fluoxetine Fluoxetine - administration & dosage Fluoxetine - pharmacology Hypothalamus - metabolism Injections, Intraperitoneal Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Neuropharmacology Neuroscience Neurosciences NMR Nuclear magnetic resonance Original Investigation Pediatrics Pharmacology. Drug treatments Pharmacology/Toxicology Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar Serotonin Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - metabolism Serotonin transporter Serotonin uptake inhibitors Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - pharmacology Structure-function relationships Substance abuse treatment
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