Dopamine depresses melanin concentrating hormone neuronal activity through multiple effects on α2-noradrenergic, D1 and D2-like dopaminergic receptors

Abstract Two neuronal populations of the lateral hypothalamus that, respectively, produce melanin-concentrating hormone (MCH) and orexin peptides are crucially involved in control of metabolism, feeding and related goal-oriented behaviors. In contrast to orexin neurons, mainly involved in short-term...

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Veröffentlicht in:	Neuroscience 2011-03, Vol.178, p.89-100
Hauptverfasser:	Conductier, G, Nahon, J.-L, Guyon, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Action Potentials - drug effects Action Potentials - physiology Animals brain slice Dopamine Dopamine - pharmacology Dopamine - physiology Dose-Response Relationship, Drug Hypothalamic Hormones Hypothalamic Hormones - genetics Hypothalamic Hormones - metabolism Hypothalamus Hypothalamus - drug effects Hypothalamus - physiology lateral hypothalamus Life Sciences Male MCH-GFP transgenic mouse melanin concentrating hormone neurons Melanins Melanins - genetics Melanins - metabolism Membrane Potentials Membrane Potentials - drug effects Membrane Potentials - physiology Mice Mice, Inbred C57BL Mice, Transgenic Neurology Neurons Neurons - metabolism Neurons - physiology Neurons and Cognition patch-clamp Patch-Clamp Techniques Pituitary Hormones Pituitary Hormones - genetics Pituitary Hormones - metabolism Receptors, Adrenergic, alpha-2 Receptors, Adrenergic, alpha-2 - physiology Receptors, Dopamine D1 Receptors, Dopamine D1 - physiology Receptors, Dopamine D2 Receptors, Dopamine D2 - physiology Synaptic Transmission Synaptic Transmission - drug effects Synaptic Transmission - physiology
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