On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons
Under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. This is a robust effect that is not usually explored in experiments or explicitly implemented or tested in models. However, the range of current strength needed for a depolarization...
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| Veröffentlicht in: | Journal of computational neuroscience 2012-10, Vol.33 (2), p.207-225 |
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| container_title | Journal of computational neuroscience |
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| creator | Bianchi, Daniela Marasco, Addolorata Limongiello, Alessandro Marchetti, Cristina Marie, Helene Tirozzi, Brunello Migliore, Michele |
| description | Under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. This is a robust effect that is not usually explored in experiments or explicitly implemented or tested in models. However, the range of current strength needed for a depolarization block could be easily reached with a random background activity of only a few hundred excitatory synapses. Depolarization block may thus be an important property of neurons that should be better characterized in experiments and explicitly taken into account in models at all implementation scales. Here we analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specific ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to a depolarization block. We suggest that this can be one of the rate-limiting mechanisms protecting a CA1 neuron from excessive spiking activity. |
| doi_str_mv | 10.1007/s10827-012-0383-y |
| format | Article |
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This is a robust effect that is not usually explored in experiments or explicitly implemented or tested in models. However, the range of current strength needed for a depolarization block could be easily reached with a random background activity of only a few hundred excitatory synapses. Depolarization block may thus be an important property of neurons that should be better characterized in experiments and explicitly taken into account in models at all implementation scales. Here we analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specific ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to a depolarization block. 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This is a robust effect that is not usually explored in experiments or explicitly implemented or tested in models. However, the range of current strength needed for a depolarization block could be easily reached with a random background activity of only a few hundred excitatory synapses. Depolarization block may thus be an important property of neurons that should be better characterized in experiments and explicitly taken into account in models at all implementation scales. Here we analyze the spiking dynamics of CA1 pyramidal neuron models using the same set of ionic currents on both an accurate morphological reconstruction and on its reduction to a single-compartment. The results show the specific ion channel properties and kinetics that are needed to reproduce the experimental findings, and how their interplay can drastically modulate the neuronal dynamics and the input current range leading to a depolarization block. 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of computational neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bianchi, Daniela</au><au>Marasco, Addolorata</au><au>Limongiello, Alessandro</au><au>Marchetti, Cristina</au><au>Marie, Helene</au><au>Tirozzi, Brunello</au><au>Migliore, Michele</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons</atitle><jtitle>Journal of computational neuroscience</jtitle><stitle>J Comput Neurosci</stitle><addtitle>J Comput Neurosci</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>33</volume><issue>2</issue><spage>207</spage><epage>225</epage><pages>207-225</pages><issn>0929-5313</issn><eissn>1573-6873</eissn><coden>JCNEFR</coden><abstract>Under sustained input current of increasing strength neurons eventually stop firing, entering a depolarization block. 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| ispartof | Journal of computational neuroscience, 2012-10, Vol.33 (2), p.207-225 |
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| subjects | Action Potentials Action Potentials - drug effects Action Potentials - physiology alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid - pharmacology Animals Animals, Newborn Biomedical and Life Sciences Biomedicine Biophysical Phenomena Biophysical Processes CA1 Region, Hippocampal CA1 Region, Hippocampal - cytology CA1 Region, Hippocampal - drug effects Computational neuroscience Electric Stimulation Excitatory Amino Acid Agonists Excitatory Amino Acid Agonists - pharmacology Firing pattern Hippocampus Hippocampus - cytology Human Genetics In Vitro Techniques Ion channels Kinetics Life Sciences Models, Neurological N-Methylaspartate N-Methylaspartate - pharmacology Neurology Neurons Neurons and Cognition Neurosciences Nonlinear Dynamics Patch-Clamp Techniques Pyramidal Cells Pyramidal Cells - physiology Rats Rats, Sprague-Dawley Synapses Synapses - drug effects Synapses - physiology Synaptic strength Theory of Computation |
| title | On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons |
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