Kavain analogues as potential analgesic agents

Kavalactones are pharmacologically active compounds present in preparations of the root trunk of Piper methysticum Forst, known as kava. This work describes the analgesic activity of some synthesized analogues of synthetic kavain, which is the main component of kava. The essays were initially perfor...

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Veröffentlicht in:	Pharmacological reports 2012, Vol.64 (6), p.1419-1426
Hauptverfasser:	Kormann, Elaine C., de Aguiar Amaral, Patricia, David, Michele, Eifler-Lima, Vera L., Filho, Valdir Cechinel, de Campos Buzzi, Fátima
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - chemical synthesis Analgesics - pharmacology Animals antinociceptive activity Behavior, Animal - drug effects Biochemistry Biochemistry, Molecular Biology Disease Models, Animal Dose-Response Relationship, Drug Drug Safety and Pharmacovigilance enol ethers kavain lactones Life Sciences Male Mice Molecular Structure Motor Activity - drug effects Pain - etiology Pain - physiopathology Pain - prevention & control Pain - psychology Pain Measurement Pain Threshold - drug effects Pharmacotherapy Pharmacy Psychomotor Performance - drug effects Pyrones - chemical synthesis Pyrones - pharmacology Structure-Activity Relationship δ-valerolactones
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