Genetic and epigenetic determinants of DNA replication origins, position and activation
In the genome of eukaryotic cells, DNA synthesis is initiated at multiple sites called origins of DNA replication. Origins must fire only once per cell cycle and how this is achieved is now well understood. However, little is known about the mechanisms that determine when and where replication initi...
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| Veröffentlicht in: | Current opinion in genetics & development 2013-04, Vol.23 (2), p.124-131 |
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| creator | Méchali, Marcel Yoshida, Kazumasa Coulombe, Philippe Pasero, Philippe |
| description | In the genome of eukaryotic cells, DNA synthesis is initiated at multiple sites called origins of DNA replication. Origins must fire only once per cell cycle and how this is achieved is now well understood. However, little is known about the mechanisms that determine when and where replication initiates in a given cell. A large body of evidence indicates that origins are not equal in terms of efficiency and timing of activation. Origin usage also changes concomitantly with the different cell differentiation programs. As DNA replication occurs in the context of chromatin, initiation could be influenced by multiple parameters, such as nucleosome positioning, histone modifications, and three-dimensional (3D) organization of the nucleus. This view is supported by recent genome-wide studies showing that DNA replication profiles are shaped by genetic and epigenetic processes that act both at the local and global levels to regulate origin function in eukaryotic cells. |
| doi_str_mv | 10.1016/j.gde.2013.02.010 |
| format | Article |
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Origins must fire only once per cell cycle and how this is achieved is now well understood. However, little is known about the mechanisms that determine when and where replication initiates in a given cell. A large body of evidence indicates that origins are not equal in terms of efficiency and timing of activation. Origin usage also changes concomitantly with the different cell differentiation programs. As DNA replication occurs in the context of chromatin, initiation could be influenced by multiple parameters, such as nucleosome positioning, histone modifications, and three-dimensional (3D) organization of the nucleus. 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Origins must fire only once per cell cycle and how this is achieved is now well understood. However, little is known about the mechanisms that determine when and where replication initiates in a given cell. A large body of evidence indicates that origins are not equal in terms of efficiency and timing of activation. Origin usage also changes concomitantly with the different cell differentiation programs. As DNA replication occurs in the context of chromatin, initiation could be influenced by multiple parameters, such as nucleosome positioning, histone modifications, and three-dimensional (3D) organization of the nucleus. This view is supported by recent genome-wide studies showing that DNA replication profiles are shaped by genetic and epigenetic processes that act both at the local and global levels to regulate origin function in eukaryotic cells.</description><subject>Cell Cycle</subject><subject>Chromatin - genetics</subject><subject>DNA Replication - genetics</subject><subject>Epigenesis, Genetic - genetics</subject><subject>Eukaryota - genetics</subject><subject>Genetics</subject><subject>Genome</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Medical Education</subject><subject>Nucleosomes - genetics</subject><subject>Replication Origin - genetics</subject><subject>Replicon - genetics</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><issn>0959-437X</issn><issn>1879-0380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEURS0EomnhB7BBswSJCe_Z8ymkSlEpLVIEC0Cwszz2m-AwsQd7Eqn_Hk8TumDByvLTuXdxLmMvEJYIWL3dLjeGlhxQLIEvAeERW2BTtzmIBh6zBbRlmxei_nHGzmPcAgBHrJ6yMy7KAkteLtj3G3I0WZ0pZzIa7eb0NTRR2Fmn3BQz32fvP62yQONgtZqsd5kPdmNdfJONPtr7y1yg9GQP98Az9qRXQ6Tnp_eCfftw_fXqNl9_vvl4tVrnuoRmykn1FXa9KUxNZdlh32mtDe8Mp7bjQhuFddP0yiApUE3XKlWhprpri9ZgWYgL9vrY-1MNcgx2p8Kd9MrK29VazjeAhheiKg6Y2FdHdgz-957iJHc2ahoG5cjvo0RRCig48CqheER18DEG6h-6EeTsXm5lci9n9xK4TO5T5uWpft_tyDwk_spOwLsjQEnIwVKQUVtymowNpCdpvP1v_eU_aT1Yl_YYftEdxa3fB5dMS5QxBeSXefx5exTz7g0XfwAM9KpB</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Méchali, Marcel</creator><creator>Yoshida, Kazumasa</creator><creator>Coulombe, Philippe</creator><creator>Pasero, Philippe</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-5891-0822</orcidid><orcidid>https://orcid.org/0000-0002-4638-9694</orcidid></search><sort><creationdate>20130401</creationdate><title>Genetic and epigenetic determinants of DNA replication origins, position and activation</title><author>Méchali, Marcel ; Yoshida, Kazumasa ; Coulombe, Philippe ; Pasero, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-eaf61bfd4d7e55b1fbcccd2bd2e9b23cda1788fad1ea0a8b9aa61ce7b949d1543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Cell Cycle</topic><topic>Chromatin - genetics</topic><topic>DNA Replication - genetics</topic><topic>Epigenesis, Genetic - genetics</topic><topic>Eukaryota - genetics</topic><topic>Genetics</topic><topic>Genome</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Medical Education</topic><topic>Nucleosomes - genetics</topic><topic>Replication Origin - genetics</topic><topic>Replicon - genetics</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Méchali, Marcel</creatorcontrib><creatorcontrib>Yoshida, Kazumasa</creatorcontrib><creatorcontrib>Coulombe, Philippe</creatorcontrib><creatorcontrib>Pasero, Philippe</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Current opinion in genetics & development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Méchali, Marcel</au><au>Yoshida, Kazumasa</au><au>Coulombe, Philippe</au><au>Pasero, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic and epigenetic determinants of DNA replication origins, position and activation</atitle><jtitle>Current opinion in genetics & development</jtitle><addtitle>Curr Opin Genet Dev</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>23</volume><issue>2</issue><spage>124</spage><epage>131</epage><pages>124-131</pages><issn>0959-437X</issn><eissn>1879-0380</eissn><abstract>In the genome of eukaryotic cells, DNA synthesis is initiated at multiple sites called origins of DNA replication. 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| ispartof | Current opinion in genetics & development, 2013-04, Vol.23 (2), p.124-131 |
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| subjects | Cell Cycle Chromatin - genetics DNA Replication - genetics Epigenesis, Genetic - genetics Eukaryota - genetics Genetics Genome Humans Life Sciences Medical Education Nucleosomes - genetics Replication Origin - genetics Replicon - genetics Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism |
| title | Genetic and epigenetic determinants of DNA replication origins, position and activation |
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