Treatment of Crohn disease in adults
Corticosteroids are an efficient treatment for active Crohn's disease. The treatment has to be undertaken with a daily intake equivalent to 1 mg/kg per day of prednisolone for a 3 to 7 week period. Immunosuppressive agents are indicated in case of corticodependency or in case of large intestina...
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| Veröffentlicht in: | La revue de medecine interne 1994, Vol.15 (10), p.676-89 |
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| container_title | La revue de medecine interne |
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| creator | Bellanger, J Cosnes, J Gendre, J P Beaugerie, L Malafosse, M Le Quintrec, Y |
| description | Corticosteroids are an efficient treatment for active Crohn's disease. The treatment has to be undertaken with a daily intake equivalent to 1 mg/kg per day of prednisolone for a 3 to 7 week period. Immunosuppressive agents are indicated in case of corticodependency or in case of large intestinal resection. Artificial nutrition (enteral or parenteral) is proposed in corticoresistant forms, and is usually followed by an immunosuppressive therapy. Surgical management is reserved for complications, including resistance to all medical therapy. Surgical resection has to be limited in order to avoid a short bowel syndrome. Surgery should not be considered as the ideal therapy as it has been demonstrated that recurrence after surgery increases at distance. 5-aminosalycilates compounds are an alternative therapy in mild attacks. Mesalazine may reduce the recurrence and could be considered as a possible maintenance treatment. |
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The treatment has to be undertaken with a daily intake equivalent to 1 mg/kg per day of prednisolone for a 3 to 7 week period. Immunosuppressive agents are indicated in case of corticodependency or in case of large intestinal resection. Artificial nutrition (enteral or parenteral) is proposed in corticoresistant forms, and is usually followed by an immunosuppressive therapy. Surgical management is reserved for complications, including resistance to all medical therapy. Surgical resection has to be limited in order to avoid a short bowel syndrome. Surgery should not be considered as the ideal therapy as it has been demonstrated that recurrence after surgery increases at distance. 5-aminosalycilates compounds are an alternative therapy in mild attacks. 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The treatment has to be undertaken with a daily intake equivalent to 1 mg/kg per day of prednisolone for a 3 to 7 week period. Immunosuppressive agents are indicated in case of corticodependency or in case of large intestinal resection. Artificial nutrition (enteral or parenteral) is proposed in corticoresistant forms, and is usually followed by an immunosuppressive therapy. Surgical management is reserved for complications, including resistance to all medical therapy. Surgical resection has to be limited in order to avoid a short bowel syndrome. Surgery should not be considered as the ideal therapy as it has been demonstrated that recurrence after surgery increases at distance. 5-aminosalycilates compounds are an alternative therapy in mild attacks. Mesalazine may reduce the recurrence and could be considered as a possible maintenance treatment.</description><subject>Adult</subject><subject>Chemical Sciences</subject><subject>Combined Modality Therapy</subject><subject>Crohn Disease - drug therapy</subject><subject>Crohn Disease - surgery</subject><subject>Crohn Disease - therapy</subject><subject>Diet</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Organic chemistry</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - therapy</subject><issn>0248-8663</issn><issn>1768-3122</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9z0tLw0AUBeBBlBqrP0HIwo2LwL0zzmtZgtpCwE324WYeJJJHyaSC_16lxdWBw8eBc8Uy1MoUAjm_ZhnwF1MYpcQtu0vpEwAQ0G7YRhsAayFjT_USaB3DtOZzzMtl7qbc9ylQCnk_5eRPw5ru2U2kIYWHS25Z_fZal_ui-ng_lLuq6KSCwjiSLkhsreUuchsccumj8ByiCspDbHm0QZN20qPziMiVBEOOUGhlxZY9n2c7Gprj0o-0fDcz9c1-VzV_HYBBKdB84a99PNvjqR2D_-eXY-IHQopIhQ</recordid><startdate>1994</startdate><enddate>1994</enddate><creator>Bellanger, J</creator><creator>Cosnes, J</creator><creator>Gendre, J P</creator><creator>Beaugerie, L</creator><creator>Malafosse, M</creator><creator>Le Quintrec, Y</creator><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>1XC</scope></search><sort><creationdate>1994</creationdate><title>Treatment of Crohn disease in adults</title><author>Bellanger, J ; Cosnes, J ; Gendre, J P ; Beaugerie, L ; Malafosse, M ; Le Quintrec, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h560-8ca5ce51b992cf29ec125df3d20f6e6d0fb2f9e7a7c5d1cd11126508aca137693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Chemical Sciences</topic><topic>Combined Modality Therapy</topic><topic>Crohn Disease - drug therapy</topic><topic>Crohn Disease - surgery</topic><topic>Crohn Disease - therapy</topic><topic>Diet</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Organic chemistry</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bellanger, J</creatorcontrib><creatorcontrib>Cosnes, J</creatorcontrib><creatorcontrib>Gendre, J P</creatorcontrib><creatorcontrib>Beaugerie, L</creatorcontrib><creatorcontrib>Malafosse, M</creatorcontrib><creatorcontrib>Le Quintrec, Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>La revue de medecine interne</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bellanger, J</au><au>Cosnes, J</au><au>Gendre, J P</au><au>Beaugerie, L</au><au>Malafosse, M</au><au>Le Quintrec, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Crohn disease in adults</atitle><jtitle>La revue de medecine interne</jtitle><addtitle>Rev Med Interne</addtitle><date>1994</date><risdate>1994</risdate><volume>15</volume><issue>10</issue><spage>676</spage><epage>89</epage><pages>676-89</pages><issn>0248-8663</issn><eissn>1768-3122</eissn><abstract>Corticosteroids are an efficient treatment for active Crohn's disease. 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| identifier | ISSN: 0248-8663 |
| ispartof | La revue de medecine interne, 1994, Vol.15 (10), p.676-89 |
| issn | 0248-8663 1768-3122 |
| language | fre |
| recordid | cdi_hal_primary_oai_HAL_hal_00815318v1 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Chemical Sciences Combined Modality Therapy Crohn Disease - drug therapy Crohn Disease - surgery Crohn Disease - therapy Diet Female Humans Male Organic chemistry Pregnancy Pregnancy Complications - therapy |
| title | Treatment of Crohn disease in adults |
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