MC1R expression in HaCaT keratinocytes inhibits UVA-induced ROS production via NADPH Oxidase- and cAMP-dependent mechanisms

Ultraviolet A (UVA) radiations are responsible for deleterious effects, mainly due to reactive oxygen species (ROS) production. Alpha‐melanocyte stimulating hormone (α‐MSH) binds to melanocortin‐1 receptor (MC1R) in melanocytes to stimulate pigmentation and modulate cutaneous inflammatory responses....

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Veröffentlicht in:	Journal of cellular physiology 2012-06, Vol.227 (6), p.2578-2585
Hauptverfasser:	Henri, Pauline, Beaumel, Sylvain, Guezennec, Anne, Poumès, Carine, Stoebner, Pierre-Emmanuel, Stasia, Marie-José, Guesnet, Joëlle, Martinez, Jean, Meunier, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Vesicular Transport Adaptor Proteins, Vesicular Transport - metabolism alpha-MSH alpha-MSH - metabolism Cell Line Cyclic AMP Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Dose-Response Relationship, Radiation Extracellular Signal-Regulated MAP Kinases Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors Extracellular Signal-Regulated MAP Kinases - metabolism Humans Immunology Innate immunity Irradiation Keratinocytes Keratinocytes - drug effects Keratinocytes - enzymology Keratinocytes - radiation effects Life Sciences NADPH Oxidase NADPH Oxidases - metabolism Oxidative Stress Oxidative Stress - drug effects Oxidative Stress - radiation effects Phosphorylation Pigmentation Protein Kinase Inhibitors Protein Kinase Inhibitors - pharmacology Reactive Oxygen Species Reactive Oxygen Species - metabolism Receptor, Epidermal Growth Factor Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Receptor, Melanocortin, Type 1 Receptor, Melanocortin, Type 1 - genetics Receptor, Melanocortin, Type 1 - metabolism Signal Transduction Signal Transduction - radiation effects Time Factors Transfection Ultraviolet Rays
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