The in vivo behavior and antitumor activity of doxorubicin-loaded poly(γ-benzyl l -glutamate)- block -hyaluronan polymersomes in Ehrlich ascites tumor-bearing BalB/c mice

Abstract The in vivo efficacy of doxorubicin (DOX)-loaded poly(γ-benzyl l -glutamate)- block -hyaluronan (PBLG23 - b -HYA10 )-based polymersomes (PolyDOX) was evaluated. Samples were efficiently labeled with technetium-99m radionuclide with good stability for in vivo studies. PolyDOX enhanced circul...

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Veröffentlicht in:	Nanomedicine 2012-01, Vol.8 (1), p.71-80
Hauptverfasser:	Upadhyay, Kamal Kumar, PhD, Mishra, Anil Kumar, PhD, Chuttani, Krishna, MSc, Kaul, Ankur, MSc, Schatz, Christophe, PhD, Le Meins, Jean-François, PhD, Misra, Ambikanandan, PhD, Lecommandoux, Sebastien, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - blood Antineoplastic Agents - chemical synthesis Antineoplastic Agents - therapeutic use Antitumor activity Carcinoma, Ehrlich Tumor - drug therapy Chemical Sciences Doxorubicin Doxorubicin - administration & dosage Doxorubicin - adverse effects Doxorubicin - blood Doxorubicin - chemical synthesis Doxorubicin - therapeutic use Drug Carriers - administration & dosage Drug Carriers - adverse effects Drug Carriers - chemistry Ehrlich ascites tumor (EAT) Endocytosis - immunology Female Humans Hyaluronan Hyaluronan Receptors - immunology Hyaluronic Acid - administration & dosage Hyaluronic Acid - adverse effects Hyaluronic Acid - analogs & derivatives Hyaluronic Acid - blood Hyaluronic Acid - chemistry Hyaluronic Acid - therapeutic use Internal Medicine Mice Mice, Inbred BALB C Nanoparticles - administration & dosage Nanoparticles - adverse effects Nanoparticles - chemistry Neoplasms, Experimental - drug therapy Polyglutamic Acid - administration & dosage Polyglutamic Acid - adverse effects Polyglutamic Acid - analogs & derivatives Polyglutamic Acid - blood Polyglutamic Acid - chemistry Polyglutamic Acid - therapeutic use Polymers Polymersomes Rabbits Technetium - chemistry
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