A synthetic peptide derived from the parasite Toxoplasma gondii triggers human dendritic cells' migration

Pep29, a peptide derived from the Toxoplasma GRA5 protein, is responsible for human dendritic cellsˈ migration toward the CCR7 ligand. The migration of DCs is a critical function, enabling information to be carried to where the immunological response occurs. Parasites are known to weaken host immuni...

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Veröffentlicht in:	Journal of leukocyte biology 2012-12, Vol.92 (6), p.1241-1250
Hauptverfasser:	Persat, Florence, Mercier, Corinne, Ficheux, Damien, Colomb, Evelyne, Trouillet, Sophie, Bendridi, Nadia, Musset, Karine, Loeuillet, Corinne, Cesbron‐Delauw, Marie‐France, Vincent, Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens, CD34 Antigens, CD34 - metabolism Antigens, Protozoan Antigens, Protozoan - chemistry Antigens, Protozoan - immunology Antigens, Protozoan - metabolism Antigens, Protozoan - pharmacology Biochemistry, Molecular Biology CCR7 Cell Movement Cell Movement - drug effects Cell Movement - immunology Cells, Cultured Chemokine CCL19 Chemokine CCL19 - immunology Chemokine CCL19 - metabolism Dendritic Cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism ESA GRA5 Humans Immunology Immunophenotyping Langerhans Cells Langerhans Cells - immunology Langerhans Cells - metabolism Life Sciences MAP Kinase Signaling System Microbiology and Parasitology Molecular Sequence Data Peptides Peptides - chemistry Peptides - immunology Peptides - metabolism Peptides - pharmacology Pinocytosis Pinocytosis - immunology Protein Interaction Domains and Motifs Protein Interaction Domains and Motifs - immunology Protein Sorting Signals Protozoan Proteins Protozoan Proteins - chemistry Protozoan Proteins - immunology Receptors, CCR7 Receptors, CCR7 - metabolism Skin Skin - immunology synthetic peptide Toxoplasma Toxoplasma - chemistry Toxoplasma - immunology Toxoplasma gondii
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