Switching the nucleoside reverse transcriptase inhibitor backbone to tenofovir disoproxil fumarate + emtricitabine promptly improves triglycerides and low-density lipoprotein cholesterol in dyslipidaemic patients

Objectives To assess the impact of switching to tenofovir disoproxil fumarate + emtricitabine on lipid parameters. Methods HIV-infected patients with plasma viral load 4.1 mmol/L were randomized to switch the nucleoside reverse transcriptase inhibitor (NRTI) backbone to fixed-dose combination tenofo...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2010-03, Vol.65 (3), p.556-561
Hauptverfasser:	Valantin, M. A., Bittar, R., de Truchis, P., Bollens, D., Slama, L., Giral, P., Bonnefont-Rousselot, D., Pétour, P., Aubron-Olivier, C., Costagliola, D., Katlama, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adenine - adverse effects Adenine - analogs & derivatives Adenine - therapeutic use Adult Anti-HIV Agents Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiviral agents Biological and medical sciences Cholesterol Cholesterol, LDL Cholesterol, LDL - blood Deoxycytidine Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drug therapy Emtricitabine Female HIV HIV infection HIV Infections HIV Infections - drug therapy Human health and pathology Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Inhibitor drugs Life Sciences lipid abnormalities Lipids Lipoproteins Low density lipoprotein Male Medical sciences Middle Aged nucleoside reverse transcriptase inhibitors Nucleosides Nucleosides - adverse effects Nucleosides - therapeutic use Organophosphonates Organophosphonates - adverse effects Organophosphonates - therapeutic use Pharmacology. Drug treatments Tenofovir Triglycerides Triglycerides - blood Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral infections
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