Plant-specific multisubunit RNA polymerase in gene silencing
In recent years, a major breakthrough in the study of epigenetic silencing in eukaryotes came with the discovery that the RNA-interference pathway (RNAi) is generally implicated in heterochromatin assembly and gene silencing. An important and paradoxical feature of the RNAi-mediated heterochromatin...
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| description | In recent years, a major breakthrough in the study of epigenetic silencing in eukaryotes came with the discovery that the RNA-interference pathway (RNAi) is generally implicated in heterochromatin assembly and gene silencing. An important and paradoxical feature of the RNAi-mediated heterochromatin pathways is their requirement for some form of transcription. In fission yeast, Schizosaccharomyces pombe, centromeric siRNAs have been shown to derive from chromatin-bound nascent transcripts produced by RNA polymerase II (PolII) at the site of heterochromatin formation. Likewise, chromatin-bound nascent transcripts generated by a PolII-related DNA-dependent RNA polymerase, known as PolIVb/PolV, have recently been implicated in RNA-directed DNA methylation (RdDM), the prominent RNAi-mediated chromatin pathway in plants. In this review we discuss recent work on the plant-specific PolII variant enzymes and discuss the mechanistic convergences that have been observed in the role of these enzymes in their respective siRNA-mediated heterochromatin formation pathways. |
| doi_str_mv | 10.4161/epi.5.1.10435 |
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An important and paradoxical feature of the RNAi-mediated heterochromatin pathways is their requirement for some form of transcription. In fission yeast, Schizosaccharomyces pombe, centromeric siRNAs have been shown to derive from chromatin-bound nascent transcripts produced by RNA polymerase II (PolII) at the site of heterochromatin formation. Likewise, chromatin-bound nascent transcripts generated by a PolII-related DNA-dependent RNA polymerase, known as PolIVb/PolV, have recently been implicated in RNA-directed DNA methylation (RdDM), the prominent RNAi-mediated chromatin pathway in plants. 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In this review we discuss recent work on the plant-specific PolII variant enzymes and discuss the mechanistic convergences that have been observed in the role of these enzymes in their respective siRNA-mediated heterochromatin formation pathways.</description><subject>Arabidopsis</subject><subject>Arabidopsis - genetics</subject><subject>Binding</subject><subject>Biochemistry</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biodiversity</subject><subject>Bioinformatics</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cellular Biology</subject><subject>Centromere</subject><subject>Centromere - ultrastructure</subject><subject>Chromatin</subject><subject>Chromatin - metabolism</subject><subject>Computer Science</subject><subject>Cycle</subject><subject>DNA Methylation</subject><subject>DNA-Directed RNA Polymerases</subject><subject>DNA-Directed RNA Polymerases - chemistry</subject><subject>DNA-Directed RNA Polymerases - genetics</subject><subject>Gene Silencing</subject><subject>Genetics</subject><subject>Genomics</subject><subject>Heterochromatin</subject><subject>Heterochromatin - chemistry</subject><subject>Heterochromatin - metabolism</subject><subject>Landes</subject><subject>Life Sciences</subject><subject>Models, Biological</subject><subject>Molecular biology</subject><subject>Molecular Networks</subject><subject>Organogenesis</subject><subject>Plant breeding</subject><subject>Plants</subject><subject>Plants - enzymology</subject><subject>Plants - genetics</subject><subject>Populations and Evolution</subject><subject>Proteins</subject><subject>Quantitative Methods</subject><subject>RNA Interference</subject><subject>RNA Polymerase II</subject><subject>RNA Polymerase II - metabolism</subject><subject>RNA, Small Interfering</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Schizosaccharomyces</subject><subject>Schizosaccharomyces - genetics</subject><subject>Schizosaccharomyces pombe Proteins</subject><subject>Schizosaccharomyces pombe Proteins - metabolism</subject><subject>Structural Biology</subject><subject>Systematics, Phylogenetics and taxonomy</subject><subject>Transcription, Genetic</subject><subject>Vegetal Biology</subject><issn>1559-2294</issn><issn>1559-2308</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFr3DAQRkVpadK0x16LbyUHbyRLsizoZQlJE1jaENKzmJXHiYpsuZKdsP8-2jrZU6GnEeLNp5knQj4zuhKsZmc4upVcsRWjgss35JhJqcuK0-bt67nS4oh8SOk3zUit9XtyVFGmuKjoMfl242GYyjSidZ2zRT_7yaV5Ow9uKm5_rIsx-F2PERIWbijuccAiOY-DdcP9R_KuA5_w00s9Ib8uL-7Or8rNz-_X5-tNaSUVU2mFZbTmaFsKkqm2kcil4FoLpkB2VKhK1fW2rbkG24KlvFGUssYqIUBo4CfkdMl9AG_G6HqIOxPAmav1xuzvKFVNw5h4ZJn9urBjDH9mTJPpXbLo85oY5mQU53UjuFKZLBfSxpBSxO4QzajZuzXZrZGGmb9uM__lJXne9tge6FeZGdALkN9qMW1dSNZlU3hAc-De4ORsMhBz8XgIP_tP7wYe-t3FzfV-oLHtckezdLihC7GHpxB9aybY-RC7CPmDkuH_3uQZfZms7A</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Lahmy, Sylvie</creator><creator>Bies-Etheve, Natacha</creator><creator>Lagrange, Thierry</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-3090-0918</orcidid></search><sort><creationdate>20100101</creationdate><title>Plant-specific multisubunit RNA polymerase in gene silencing</title><author>Lahmy, Sylvie ; Bies-Etheve, Natacha ; Lagrange, Thierry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-c4c1063ecd0a517d85e354399417a5f0472766bd639acdac03870018c744a49a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Arabidopsis</topic><topic>Arabidopsis - genetics</topic><topic>Binding</topic><topic>Biochemistry</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biodiversity</topic><topic>Bioinformatics</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cellular Biology</topic><topic>Centromere</topic><topic>Centromere - ultrastructure</topic><topic>Chromatin</topic><topic>Chromatin - metabolism</topic><topic>Computer Science</topic><topic>Cycle</topic><topic>DNA Methylation</topic><topic>DNA-Directed RNA Polymerases</topic><topic>DNA-Directed RNA Polymerases - chemistry</topic><topic>DNA-Directed RNA Polymerases - genetics</topic><topic>Gene Silencing</topic><topic>Genetics</topic><topic>Genomics</topic><topic>Heterochromatin</topic><topic>Heterochromatin - chemistry</topic><topic>Heterochromatin - metabolism</topic><topic>Landes</topic><topic>Life Sciences</topic><topic>Models, Biological</topic><topic>Molecular biology</topic><topic>Molecular Networks</topic><topic>Organogenesis</topic><topic>Plant breeding</topic><topic>Plants</topic><topic>Plants - enzymology</topic><topic>Plants - genetics</topic><topic>Populations and Evolution</topic><topic>Proteins</topic><topic>Quantitative Methods</topic><topic>RNA Interference</topic><topic>RNA Polymerase II</topic><topic>RNA Polymerase II - metabolism</topic><topic>RNA, Small Interfering</topic><topic>RNA, Small Interfering - metabolism</topic><topic>Schizosaccharomyces</topic><topic>Schizosaccharomyces - genetics</topic><topic>Schizosaccharomyces pombe Proteins</topic><topic>Schizosaccharomyces pombe Proteins - metabolism</topic><topic>Structural Biology</topic><topic>Systematics, Phylogenetics and taxonomy</topic><topic>Transcription, Genetic</topic><topic>Vegetal Biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lahmy, Sylvie</creatorcontrib><creatorcontrib>Bies-Etheve, Natacha</creatorcontrib><creatorcontrib>Lagrange, Thierry</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Epigenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lahmy, Sylvie</au><au>Bies-Etheve, Natacha</au><au>Lagrange, Thierry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant-specific multisubunit RNA polymerase in gene silencing</atitle><jtitle>Epigenetics</jtitle><addtitle>Epigenetics</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>5</volume><issue>1</issue><spage>4</spage><epage>8</epage><pages>4-8</pages><issn>1559-2294</issn><eissn>1559-2308</eissn><abstract>In recent years, a major breakthrough in the study of epigenetic silencing in eukaryotes came with the discovery that the RNA-interference pathway (RNAi) is generally implicated in heterochromatin assembly and gene silencing. An important and paradoxical feature of the RNAi-mediated heterochromatin pathways is their requirement for some form of transcription. In fission yeast, Schizosaccharomyces pombe, centromeric siRNAs have been shown to derive from chromatin-bound nascent transcripts produced by RNA polymerase II (PolII) at the site of heterochromatin formation. Likewise, chromatin-bound nascent transcripts generated by a PolII-related DNA-dependent RNA polymerase, known as PolIVb/PolV, have recently been implicated in RNA-directed DNA methylation (RdDM), the prominent RNAi-mediated chromatin pathway in plants. In this review we discuss recent work on the plant-specific PolII variant enzymes and discuss the mechanistic convergences that have been observed in the role of these enzymes in their respective siRNA-mediated heterochromatin formation pathways.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>20173420</pmid><doi>10.4161/epi.5.1.10435</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-3090-0918</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arabidopsis Arabidopsis - genetics Binding Biochemistry Biochemistry, Molecular Biology Biodiversity Bioinformatics Biology Bioscience Calcium Cancer Cell Cellular Biology Centromere Centromere - ultrastructure Chromatin Chromatin - metabolism Computer Science Cycle DNA Methylation DNA-Directed RNA Polymerases DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - genetics Gene Silencing Genetics Genomics Heterochromatin Heterochromatin - chemistry Heterochromatin - metabolism Landes Life Sciences Models, Biological Molecular biology Molecular Networks Organogenesis Plant breeding Plants Plants - enzymology Plants - genetics Populations and Evolution Proteins Quantitative Methods RNA Interference RNA Polymerase II RNA Polymerase II - metabolism RNA, Small Interfering RNA, Small Interfering - metabolism Schizosaccharomyces Schizosaccharomyces - genetics Schizosaccharomyces pombe Proteins Schizosaccharomyces pombe Proteins - metabolism Structural Biology Systematics, Phylogenetics and taxonomy Transcription, Genetic Vegetal Biology |
| title | Plant-specific multisubunit RNA polymerase in gene silencing |
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