The main Hepatitis B virus (HBV) mutants resistant to nucleoside analogs are susceptible in vitro to non-nucleoside inhibitors of HBV replication

► Non-nucleosidic compounds inhibit the main resistant mutants replication. ► Non-nucleosidic compounds acting against capsid morphogenesis are not cytotoxic. ► Combination of non-nucleosidic compounds results in inhibition of resistant mutant replication. ► Compounds targeting nucleocapsid assembly...

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Veröffentlicht in:	Antiviral research 2011-11, Vol.92 (2), p.271-276
Hauptverfasser:	Billioud, Gaëtan, Pichoud, Christian, Puerstinger, Gerhard, Neyts, Johan, Zoulim, Fabien
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - pharmacology Biological and medical sciences Cancer Cell Line Drug resistance Drug Resistance, Viral HBV Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Hepatocytes Hepatocytes - virology Human viral diseases Humans Infectious diseases Life Sciences Medical sciences Microbial Sensitivity Tests Mutation, Missense Non-nucleos(t)idic inhibitors Nucleocapsid Nucleos(t)ide analog Nucleosides Nucleosides - pharmacology Pharmacology. Drug treatments Viral diseases Viral hepatitis
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