Bevacizumab plus microtubule targeting agents in heavily pre-treated ovarian cancer patients: a retrospective study

As vascular endothelial growth factor (VEGF) is expressed in ovarian cancer, we assessed the efficacy and safety of bevacizumab (a monoclonal antibody targeting VEGF) plus microtubule targeting agents for heavily pre-treated ovarian carcinoma patients. We retrospectively reviewed 43 patients with re...

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Veröffentlicht in:	Bulletin du cancer 2011-10, Vol.98 (9), p.E80-E89
Hauptverfasser:	Asmane, Irène, Kurtz, Jean-Emmanuel, Bajard, Agathe, Guastalla, Jean-Paul, Meeus, Pierre, Tredan, Olivier, Labidi Galy, Intidhar, Moullet, Isabelle, Ardisson, Philippe, Vincent, Lionel, Coeffic, David, Dufresne, Armelle, Bergerat, Jean-Pierre, Ray-Coquard, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Angiogenesis Inhibitors Angiogenesis Inhibitors - adverse effects Angiogenesis Inhibitors - therapeutic use Antibodies, Monoclonal Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Combined Chemotherapy Protocols Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bevacizumab Cancer Carboplatin Carboplatin - administration & dosage Carboplatin - adverse effects Carcinoma, Ovarian Epithelial Cyclophosphamide Cyclophosphamide - administration & dosage Cyclophosphamide - adverse effects Docetaxel Drug Administration Schedule Female gastro-intestinal perforations Humans Intestinal Fistula Intestinal Fistula - chemically induced Intestinal Perforation Intestinal Perforation - chemically induced Life Sciences microtubule targeting agents Middle Aged Neoplasms, Glandular and Epithelial Neoplasms, Glandular and Epithelial - blood supply Neoplasms, Glandular and Epithelial - drug therapy Neoplasms, Glandular and Epithelial - mortality ovarian cancer Ovarian Neoplasms Ovarian Neoplasms - blood supply Ovarian Neoplasms - drug therapy Ovarian Neoplasms - mortality Paclitaxel Paclitaxel - administration & dosage Paclitaxel - adverse effects Rectovaginal Fistula Rectovaginal Fistula - chemically induced Retrospective Studies Taxoids Taxoids - administration & dosage Taxoids - adverse effects Treatment Outcome Urinary Bladder Fistula Urinary Bladder Fistula - chemically induced Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor A - antagonists & inhibitors Vinblastine Vinblastine - administration & dosage Vinblastine - adverse effects Vinblastine - analogs & derivatives Vinorelbine
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