Dally and Notum regulate the switch between low and high level Hedgehog pathway signalling

During development, secreted morphogens, such as Hedgehog (Hh), control cell fate and proliferation. Precise sensing of morphogen levels and dynamic cellular responses are required for morphogen-directed morphogenesis, yet the molecular mechanisms responsible are poorly understood. Several recent st...

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Veröffentlicht in:	Development (Cambridge) 2012-09, Vol.139 (17), p.3168-3179
Hauptverfasser:	Ayers, Katie L, Mteirek, Rana, Cervantes, Alexandra, Lavenant-Staccini, Laurence, Thérond, Pascal P, Gallet, Armel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Blotting, Western Cells, Cultured Development Biology Drosophila Drosophila - embryology Drosophila Proteins Drosophila Proteins - metabolism Hedgehog Proteins Hedgehog Proteins - metabolism Image Processing, Computer-Assisted Life Sciences Membrane Glycoproteins Membrane Glycoproteins - metabolism Microscopy, Fluorescence Morphogenesis Morphogenesis - physiology Proteoglycans Proteoglycans - metabolism Signal Transduction Signal Transduction - physiology
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