EGR1 expression: A calcium and ERK1/2 mediated PPAR γ-independent event involved in the antiproliferative effect of 15-deoxy-Δ12,14-prostaglandin J2 and thiazolidinediones in breast cancer cells

Troglitazone (TGZ) and Δ2-TGZ induce an increase in cytosolic calcium leading to ERK1/2 phosphorylation and EGR1 expression in breast cancer cells, leading to growth inhibition. This event is independent of PPARγ and EGFR activation. Our aim was to get new information about the Peroxisome Proliferat...

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Veröffentlicht in:	Biochemical pharmacology 2011-05, Vol.81 (9), p.1087-1097
Hauptverfasser:	Chbicheb, Sarra, Yao, Xiao, Rodeau, Jean-Luc, Salamone, Stéphane, Boisbrun, Michel, Thiel, Gerald, Spohn, Daniel, Grillier-Vuissoz, Isabelle, Chapleur, Yves, Flament, Stéphane, Mazerbourg, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	antagonists Base Sequence Biological and medical sciences Breast cancer Breast Neoplasms Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium Calcium - metabolism Calcium signaling Cancer Cell Line, Tumor Cell Proliferation Cell Proliferation - drug effects chelation DNA Primers Early Growth Response Protein 1 Early Growth Response Protein 1 - metabolism EGR1 epidermal growth factor receptors Female gene expression genes Gynecology. Andrology. Obstetrics Humans Life Sciences Mammary gland diseases Medical sciences Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase 3 - metabolism pharmacology Pharmacology. Drug treatments phosphorylation PPAR gamma PPAR gamma - metabolism Prostaglandin D2 Prostaglandin D2 - analogs & derivatives Prostaglandin D2 - pharmacology Reverse Transcriptase Polymerase Chain Reaction Thiazolidinedione Thiazolidinediones Thiazolidinediones - pharmacology transcription factors Troglitazone Tumors
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