Drug delivery by polymeric nanoparticles induces autophagy in macrophages

Drug delivery nanosystems are currently used in human therapy. In preliminary studies we have observed that Eudragit ® RS nanoparticles, prepared by nanoprecipitation or double emulsion techniques, are cytotoxic for NR8383 rat macrophages. In this study, we expand our previous analysis and suggest t...

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Veröffentlicht in:	International journal of pharmaceutics 2012-01, Vol.422 (1), p.495-503
Hauptverfasser:	Eidi, H., Joubert, O., Némos, C., Grandemange, S., Mograbi, B., Foliguet, B., Tournebize, J., Maincent, P., Le Faou, A., Aboukhamis, I., Rihn, B.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Autophagy - drug effects Blotting, Western Cell Line Chemical Precipitation Chemistry, Pharmaceutical Cytotoxicity death Drug Carriers Drug Compounding Drug delivery drugs Electron microscopy emulsions Endocytosis Fluorescent Antibody Technique Gene Expression Regulation Gene Expression Regulation - drug effects Glutathione Glutathione - metabolism humans Life Sciences Macrophages Macrophages, Alveolar Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Macrophages, Alveolar - ultrastructure Microarray microchips Microscopy, Electron, Scanning Microscopy, Electron, Transmission Mitochondria Mitochondria - drug effects Mitochondria - ultrastructure Nanoparticles Nanotechnology Oligonucleotide Array Sequence Analysis Organelles Particle Size Phagocytosis Pharmaceutical sciences Polymethacrylic Acids Polymethacrylic Acids - chemistry Polymethacrylic Acids - toxicity Rats Reactive Oxygen Species Reactive Oxygen Species - metabolism Reverse Transcriptase Polymerase Chain Reaction Technology, Pharmaceutical Technology, Pharmaceutical - methods therapeutics Toxicity Western blotting
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