A mathematical model of cartilage regeneration after cell therapy

Autologous Chondrocyte Implantation (ACI) is a cell-based therapy used mainly for the treatment of chondral defects in the knee. It involves surgically inserting isolated chondrocytes or mesenchymal stem cells (MSCs), previously expanded in culture, into the defect region. These chondrocytes then pr...

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Veröffentlicht in:	Journal of theoretical biology 2011-11, Vol.289, p.136-150
Hauptverfasser:	Lutianov, Michael, Naire, Shailesh, Roberts, Sally, Kuiper, Jan-Herman
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cartilage Cartilage, Articular - injuries Cartilage, Articular - physiology Cell Differentiation - physiology cell movement Cell Movement - physiology Cell Proliferation Chondrocytes Chondrocytes - cytology Chondrocytes - transplantation clinical trials Defect evolution extracellular matrix Extracellular Matrix - physiology Humans Knee Injuries - pathology Knee Injuries - therapy Life Sciences mathematical models Mesenchymal Stem Cell Transplantation Models, Biological Regeneration - physiology Stem cells therapeutics
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