In vitro cellular responses to silicon carbide nanoparticles: impact of physico-chemical features on pro-inflammatory and pro-oxidative effects
Silicon carbide is an extremely hard, wear resistant, and thermally stable material with particular photoluminescence and interesting biocompatibility properties. For this reason, it is largely employed for industrial applications such as ceramics. More recently, nano-sized SiC particles were expect...
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| Veröffentlicht in: | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2012-10, Vol.14 (10), p.1-12, Article 1143 |
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| creator | Pourchez, Jérémie Forest, Valérie Boumahdi, Najih Boudard, Delphine Tomatis, Maura Fubini, Bice Herlin-Boime, Nathalie Leconte, Yann Guilhot, Bernard Cottier, Michèle Grosseau, Philippe |
| description | Silicon carbide is an extremely hard, wear resistant, and thermally stable material with particular photoluminescence and interesting biocompatibility properties. For this reason, it is largely employed for industrial applications such as ceramics. More recently, nano-sized SiC particles were expected to enlarge their use in several fields such as composite supports, power electronics, biomaterials, etc. However, their large-scaled development is restricted by the potential toxicity of nanoparticles related to their manipulation and inhalation. This study aimed at synthesizing (by laser pyrolysis or sol–gel methods), characterizing physico-chemical properties of six samples of SiC nanopowders, then determining their in vitro biological impact(s). Using a macrophage cell line, toxicity was assessed in terms of cell membrane damage (LDH release), inflammatory effect (TNF-α production), and oxidative stress (reactive oxygen species generation). None of the six samples showed cytotoxicity while remarkable pro-oxidative reactions and inflammatory response were recorded, whose intensity appears related to the physico-chemical features of nano-sized SiC particles. In vitro data clearly showed an impact of the extent of nanoparticle surface area and the nature of crystalline phases (α-SiC vs. β-SiC) on the TNF-α production, a role of surface iron on free radical release, and of the oxidation state of the surface on cellular H
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| doi_str_mv | 10.1007/s11051-012-1143-7 |
| format | Article |
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production.</description><identifier>ISSN: 1388-0764</identifier><identifier>EISSN: 1572-896X</identifier><identifier>DOI: 10.1007/s11051-012-1143-7</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Biocompatibility ; Biomaterials ; Cellular ; Characterization and Evaluation of Materials ; Chemical and Process Engineering ; Chemical properties ; Chemistry and Materials Science ; Cytotoxicity ; Engineering Sciences ; Human health and pathology ; Hydrogen peroxide ; In vitro testing ; Inhalation ; Inorganic Chemistry ; Lasers ; Life Sciences ; Materials Science ; Nanocomposites ; Nanomaterials ; Nanoparticles ; Nanostructure ; Nanotechnology ; Optical Devices ; Optics ; Oxidative stress ; Photonics ; Physical Chemistry ; Pulmonology and respiratory tract ; Pyrolysis ; Research Paper ; Silicon ; Silicon carbide ; Toxicology</subject><ispartof>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2012-10, Vol.14 (10), p.1-12, Article 1143</ispartof><rights>Springer Science+Business Media B.V. 2012</rights><rights>Springer Science+Business Media Dordrecht 2012</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-cb70faa99c68d3c29442520b74bc0d8bcebea3be94a1a7ac6239cea56170c7433</citedby><cites>FETCH-LOGICAL-c426t-cb70faa99c68d3c29442520b74bc0d8bcebea3be94a1a7ac6239cea56170c7433</cites><orcidid>0000-0002-4573-6711 ; 0000-0003-3124-0413</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11051-012-1143-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11051-012-1143-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,778,782,883,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://hal.science/hal-00734434$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pourchez, Jérémie</creatorcontrib><creatorcontrib>Forest, Valérie</creatorcontrib><creatorcontrib>Boumahdi, Najih</creatorcontrib><creatorcontrib>Boudard, Delphine</creatorcontrib><creatorcontrib>Tomatis, Maura</creatorcontrib><creatorcontrib>Fubini, Bice</creatorcontrib><creatorcontrib>Herlin-Boime, Nathalie</creatorcontrib><creatorcontrib>Leconte, Yann</creatorcontrib><creatorcontrib>Guilhot, Bernard</creatorcontrib><creatorcontrib>Cottier, Michèle</creatorcontrib><creatorcontrib>Grosseau, Philippe</creatorcontrib><title>In vitro cellular responses to silicon carbide nanoparticles: impact of physico-chemical features on pro-inflammatory and pro-oxidative effects</title><title>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</title><addtitle>J Nanopart Res</addtitle><description>Silicon carbide is an extremely hard, wear resistant, and thermally stable material with particular photoluminescence and interesting biocompatibility properties. For this reason, it is largely employed for industrial applications such as ceramics. More recently, nano-sized SiC particles were expected to enlarge their use in several fields such as composite supports, power electronics, biomaterials, etc. However, their large-scaled development is restricted by the potential toxicity of nanoparticles related to their manipulation and inhalation. This study aimed at synthesizing (by laser pyrolysis or sol–gel methods), characterizing physico-chemical properties of six samples of SiC nanopowders, then determining their in vitro biological impact(s). Using a macrophage cell line, toxicity was assessed in terms of cell membrane damage (LDH release), inflammatory effect (TNF-α production), and oxidative stress (reactive oxygen species generation). None of the six samples showed cytotoxicity while remarkable pro-oxidative reactions and inflammatory response were recorded, whose intensity appears related to the physico-chemical features of nano-sized SiC particles. In vitro data clearly showed an impact of the extent of nanoparticle surface area and the nature of crystalline phases (α-SiC vs. β-SiC) on the TNF-α production, a role of surface iron on free radical release, and of the oxidation state of the surface on cellular H
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production.</description><subject>Biocompatibility</subject><subject>Biomaterials</subject><subject>Cellular</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemical and Process Engineering</subject><subject>Chemical properties</subject><subject>Chemistry and Materials Science</subject><subject>Cytotoxicity</subject><subject>Engineering Sciences</subject><subject>Human health and pathology</subject><subject>Hydrogen peroxide</subject><subject>In vitro testing</subject><subject>Inhalation</subject><subject>Inorganic Chemistry</subject><subject>Lasers</subject><subject>Life Sciences</subject><subject>Materials Science</subject><subject>Nanocomposites</subject><subject>Nanomaterials</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Nanotechnology</subject><subject>Optical Devices</subject><subject>Optics</subject><subject>Oxidative stress</subject><subject>Photonics</subject><subject>Physical Chemistry</subject><subject>Pulmonology and respiratory tract</subject><subject>Pyrolysis</subject><subject>Research Paper</subject><subject>Silicon</subject><subject>Silicon 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Bice</au><au>Herlin-Boime, Nathalie</au><au>Leconte, Yann</au><au>Guilhot, Bernard</au><au>Cottier, Michèle</au><au>Grosseau, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro cellular responses to silicon carbide nanoparticles: impact of physico-chemical features on pro-inflammatory and pro-oxidative effects</atitle><jtitle>Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology</jtitle><stitle>J Nanopart Res</stitle><date>2012-10-01</date><risdate>2012</risdate><volume>14</volume><issue>10</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><artnum>1143</artnum><issn>1388-0764</issn><eissn>1572-896X</eissn><abstract>Silicon carbide is an extremely hard, wear resistant, and thermally stable material with particular photoluminescence and interesting biocompatibility properties. For this reason, it is largely employed for industrial applications such as ceramics. More recently, nano-sized SiC particles were expected to enlarge their use in several fields such as composite supports, power electronics, biomaterials, etc. However, their large-scaled development is restricted by the potential toxicity of nanoparticles related to their manipulation and inhalation. This study aimed at synthesizing (by laser pyrolysis or sol–gel methods), characterizing physico-chemical properties of six samples of SiC nanopowders, then determining their in vitro biological impact(s). Using a macrophage cell line, toxicity was assessed in terms of cell membrane damage (LDH release), inflammatory effect (TNF-α production), and oxidative stress (reactive oxygen species generation). None of the six samples showed cytotoxicity while remarkable pro-oxidative reactions and inflammatory response were recorded, whose intensity appears related to the physico-chemical features of nano-sized SiC particles. In vitro data clearly showed an impact of the extent of nanoparticle surface area and the nature of crystalline phases (α-SiC vs. β-SiC) on the TNF-α production, a role of surface iron on free radical release, and of the oxidation state of the surface on cellular H
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production.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s11051-012-1143-7</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4573-6711</orcidid><orcidid>https://orcid.org/0000-0003-3124-0413</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology, 2012-10, Vol.14 (10), p.1-12, Article 1143 |
| issn | 1388-0764 1572-896X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_00734434v1 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Biocompatibility Biomaterials Cellular Characterization and Evaluation of Materials Chemical and Process Engineering Chemical properties Chemistry and Materials Science Cytotoxicity Engineering Sciences Human health and pathology Hydrogen peroxide In vitro testing Inhalation Inorganic Chemistry Lasers Life Sciences Materials Science Nanocomposites Nanomaterials Nanoparticles Nanostructure Nanotechnology Optical Devices Optics Oxidative stress Photonics Physical Chemistry Pulmonology and respiratory tract Pyrolysis Research Paper Silicon Silicon carbide Toxicology |
| title | In vitro cellular responses to silicon carbide nanoparticles: impact of physico-chemical features on pro-inflammatory and pro-oxidative effects |
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