Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon

Purinergic and nitrergic neurotransmission predominantly mediate inhibitory neuromuscular transmission in the rat colon. We studied the sensitivity of both purinergic and nitrergic pathways to spadin, a TWIK-related potassium channel 1 (TREK1) inhibitor, apamin, a small-conductance calcium-activated...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2012-08, Vol.303 (3), p.G412-G423
Hauptverfasser:	Gil, V, Gallego, D, Moha Ou Maati, H, Peyronnet, R, Martínez-Cutillas, M, Heurteaux, C, Borsotto, M, Jiménez, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apamin - pharmacology Colon - physiology Cysteine - pharmacology Life Sciences Male Methionine - pharmacology Muscle Relaxation - drug effects Neurons and Cognition Nitroarginine - pharmacology Nitroprusside - pharmacology Oxadiazoles - pharmacology Peptides - pharmacology Pharmaceutical sciences Potassium Channel Blockers - pharmacology Potassium Channels, Tandem Pore Domain - drug effects Potassium Channels, Tandem Pore Domain - physiology Quinoxalines - pharmacology Rats Rats, Sprague-Dawley Small-Conductance Calcium-Activated Potassium Channels - drug effects Small-Conductance Calcium-Activated Potassium Channels - physiology Synaptic Transmission - drug effects Synaptic Transmission - physiology
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