GNAS -activating mutations define a rare subgroup of inflammatory liver tumors characterized by STAT3 activation

Background & Aims Mosaic G-protein alpha-subunit ( GNAS )-activating mutations are responsible for the McCune–Albright (MCA) syndrome. This oncogene that activates the adenylate cyclase is also mutated in various tumor types leading to the accumulation of cyclic-AMP. Identification of a hepatoce...

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Veröffentlicht in:	Journal of hepatology 2012-01, Vol.56 (1), p.184-191
Hauptverfasser:	Nault, Jean Charles, Fabre, Monique, Couchy, Gabrielle, Pilati, Camilla, Jeannot, Emmanuelle, Tran Van Nhieu, Jeanne, Saint-Paul, Marie-Christine, De Muret, Anne, Redon, Marie-José, Buffet, Catherine, Salenave, Sylvie, Balabaud, Charles, Prevot, Sophie, Labrune, Philippe, Bioulac-Sage, Paulette, Scoazec, Jean-Yves, Chanson, Philippe, Zucman-Rossi, Jessica
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma, Liver Cell Adenoma, Liver Cell - genetics Adenoma, Liver Cell - metabolism Adenoma, Liver Cell - pathology Adult Aged Base Sequence Biological and medical sciences Cancer Carcinoma, Hepatocellular Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Chromogranins DNA Mutational Analysis DNA, Neoplasm DNA, Neoplasm - genetics Female Fibrous Dysplasia, Polyostotic Fibrous Dysplasia, Polyostotic - genetics Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen GTP-Binding Protein alpha Subunits, Gs GTP-Binding Protein alpha Subunits, Gs - genetics Humans Life Sciences Liver Neoplasms Liver Neoplasms - classification Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Models, Biological Mutation Signal Transduction STAT3 Transcription Factor STAT3 Transcription Factor - metabolism Tumors
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