Hypoxia modulates the effect of dihydroartemisinin on endothelial cells

Artemisinin derivatives, the current cornerstone of malaria treatment, possess also anti-angiogenic and anti-tumor activity. Hypoxia plays a crucial role both in severe malaria (as a consequence of the cytoadherence of infected erythrocytes to the microvasculature) and in cancer (due to the restrict...

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Veröffentlicht in:	Biochemical pharmacology 2011-09, Vol.82 (5), p.476-484
Hauptverfasser:	D’Alessandro, S., Basilico, N., Corbett, Y., Scaccabarozzi, D., Omodeo-Salè, F., Saresella, M., Marventano, I., Vaillant, M., Olliaro, P., Taramelli, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antimalarials - pharmacology antineoplastic agents apoptosis Apoptosis - drug effects artemisinin Artemisinins - pharmacology Ascorbic Acid - pharmacology Biological and medical sciences cell adhesion cell cycle Cell Cycle - drug effects cell growth Cell Hypoxia Cell proliferation Cell Proliferation - drug effects Cells, Cultured Dihydroartemisinin (DHA) Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism erythrocytes fluorescence Human protozoal diseases Humans Hypoxia Infectious diseases Life Sciences lipid peroxidation Lipid Peroxidation - drug effects Malaria Medical sciences metabolites normoxia Oxidative Stress oxygen Parasitic diseases patients Pharmaceutical sciences Pharmacology Pharmacology. Drug treatments Protozoal diseases Reactive Oxygen Species - metabolism toxicity
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