Pathologic Complete Response to Preoperative Chemotherapy Predicts Cure in Early-Stage Non–Small-Cell Lung Cancer: Combined Analysis of Two IFCT Randomized Trials

Our study aimed to evaluate whether pathologic complete response (pCR) in early-stage non–small-cell lung cancer (NSCLC) after neoadjuvant chemotherapy resulted in improved outcome, and to determine predictive factors for pCR. Eligible patients with stage-IB or -II NSCLC were included in two consecu...

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Veröffentlicht in:	Journal of thoracic oncology 2012-05, Vol.7 (5), p.841-849
Hauptverfasser:	Mouillet, Guillaume, Monnet, Elisabeth, Milleron, Bernard, Puyraveau, Marc, Quoix, Elisabeth, David, Philippe, Ducoloné, Alain, Molinier, Olivier, Zalcman, Gérard, Depierre, Alain, Westeel, Virginie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Chemotherapy, Adjuvant Cisplatin - administration & dosage Clinical Trials, Phase I as Topic Clinical Trials, Phase II as Topic Early-stage Female Humans Ifosfamide - administration & dosage Life Sciences Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - pathology Male Middle Aged Mitomycin - administration & dosage Neoadjuvant chemotherapy Neoadjuvant Therapy Neoplasm Staging Non–small-cell lung cancer Pathologic complete response Preoperative chemotherapy Prognosis Remission Induction Survival Rate
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