In situ forming polysaccharide-based 3D-hydrogels for cell delivery in regenerative medicine
► In situ forming polysaccharide-based gels for cell delivery in regenerative medicine. ► Chemically cross-linked with natural product derivatives to reduce toxicity. ► Thermosensitive hydrogels of polysaccharides designed to gel at body temperature. ► Composite hydrogels allow adhesion and expansio...
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| Veröffentlicht in: | Carbohydrate polymers 2012-01, Vol.87 (2), p.1013-1019 |
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| creator | Delair, Thierry |
| description | ► In situ forming polysaccharide-based gels for cell delivery in regenerative medicine. ► Chemically cross-linked with natural product derivatives to reduce toxicity. ► Thermosensitive hydrogels of polysaccharides designed to gel at body temperature. ► Composite hydrogels allow adhesion and expansion of anchorage-dependent cells. ► Reversible shear-responsive gels are 3D structures with tunable mechanical properties.
Regenerative medicine is evolving fast, in particular since the potential of stem cells has been assessed. This evolution process requires the development of new tools capable of meeting the needs of this field of investigation. Cell delivery is a crucial issue for the success of regenerative medicine as cells should be easily seeded, expanded and introduced on site with maintenance of their phenotype and their capability to develop into a neo tissue/organ. On a material standpoint, cell delivery system should meet the preceding needs but also permit an easy introduction at the site and remain without hampering tissue development. As is shown in this review, polysaccharide hydrogels, and in particular in situ forming ones, are materials with a high application potential in regenerative medicine. |
| doi_str_mv | 10.1016/j.carbpol.2011.09.069 |
| format | Article |
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Regenerative medicine is evolving fast, in particular since the potential of stem cells has been assessed. This evolution process requires the development of new tools capable of meeting the needs of this field of investigation. Cell delivery is a crucial issue for the success of regenerative medicine as cells should be easily seeded, expanded and introduced on site with maintenance of their phenotype and their capability to develop into a neo tissue/organ. On a material standpoint, cell delivery system should meet the preceding needs but also permit an easy introduction at the site and remain without hampering tissue development. As is shown in this review, polysaccharide hydrogels, and in particular in situ forming ones, are materials with a high application potential in regenerative medicine.</description><identifier>ISSN: 0144-8617</identifier><identifier>EISSN: 1879-1344</identifier><identifier>DOI: 10.1016/j.carbpol.2011.09.069</identifier><identifier>CODEN: CAPOD8</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Applied sciences ; Biological and medical sciences ; Cell delivery ; Chemical Sciences ; Exact sciences and technology ; General pharmacology ; hydrocolloids ; Hydrogels ; In situ forming ; Material chemistry ; Medical sciences ; medicine ; Natural polymers ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; phenotype ; Physicochemistry of polymers ; Polymers ; Polysaccharides ; Regenerative medicine ; Starch and polysaccharides ; stem cells ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments</subject><ispartof>Carbohydrate polymers, 2012-01, Vol.87 (2), p.1013-1019</ispartof><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-943331cf74a273f23ad029800aa46a6ceb1c61bf196d13f4949faf23259da9b93</citedby><cites>FETCH-LOGICAL-c397t-943331cf74a273f23ad029800aa46a6ceb1c61bf196d13f4949faf23259da9b93</cites><orcidid>0000-0003-0983-4557</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carbpol.2011.09.069$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24818648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00703876$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Delair, Thierry</creatorcontrib><title>In situ forming polysaccharide-based 3D-hydrogels for cell delivery in regenerative medicine</title><title>Carbohydrate polymers</title><description>► In situ forming polysaccharide-based gels for cell delivery in regenerative medicine. ► Chemically cross-linked with natural product derivatives to reduce toxicity. ► Thermosensitive hydrogels of polysaccharides designed to gel at body temperature. ► Composite hydrogels allow adhesion and expansion of anchorage-dependent cells. ► Reversible shear-responsive gels are 3D structures with tunable mechanical properties.
Regenerative medicine is evolving fast, in particular since the potential of stem cells has been assessed. This evolution process requires the development of new tools capable of meeting the needs of this field of investigation. Cell delivery is a crucial issue for the success of regenerative medicine as cells should be easily seeded, expanded and introduced on site with maintenance of their phenotype and their capability to develop into a neo tissue/organ. On a material standpoint, cell delivery system should meet the preceding needs but also permit an easy introduction at the site and remain without hampering tissue development. As is shown in this review, polysaccharide hydrogels, and in particular in situ forming ones, are materials with a high application potential in regenerative medicine.</description><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Cell delivery</subject><subject>Chemical Sciences</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>hydrocolloids</subject><subject>Hydrogels</subject><subject>In situ forming</subject><subject>Material chemistry</subject><subject>Medical sciences</subject><subject>medicine</subject><subject>Natural polymers</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>phenotype</subject><subject>Physicochemistry of polymers</subject><subject>Polymers</subject><subject>Polysaccharides</subject><subject>Regenerative medicine</subject><subject>Starch and polysaccharides</subject><subject>stem cells</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. 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Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>phenotype</topic><topic>Physicochemistry of polymers</topic><topic>Polymers</topic><topic>Polysaccharides</topic><topic>Regenerative medicine</topic><topic>Starch and polysaccharides</topic><topic>stem cells</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delair, Thierry</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Carbohydrate polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delair, Thierry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In situ forming polysaccharide-based 3D-hydrogels for cell delivery in regenerative medicine</atitle><jtitle>Carbohydrate polymers</jtitle><date>2012-01-15</date><risdate>2012</risdate><volume>87</volume><issue>2</issue><spage>1013</spage><epage>1019</epage><pages>1013-1019</pages><issn>0144-8617</issn><eissn>1879-1344</eissn><coden>CAPOD8</coden><abstract>► In situ forming polysaccharide-based gels for cell delivery in regenerative medicine. ► Chemically cross-linked with natural product derivatives to reduce toxicity. ► Thermosensitive hydrogels of polysaccharides designed to gel at body temperature. ► Composite hydrogels allow adhesion and expansion of anchorage-dependent cells. ► Reversible shear-responsive gels are 3D structures with tunable mechanical properties.
Regenerative medicine is evolving fast, in particular since the potential of stem cells has been assessed. This evolution process requires the development of new tools capable of meeting the needs of this field of investigation. Cell delivery is a crucial issue for the success of regenerative medicine as cells should be easily seeded, expanded and introduced on site with maintenance of their phenotype and their capability to develop into a neo tissue/organ. On a material standpoint, cell delivery system should meet the preceding needs but also permit an easy introduction at the site and remain without hampering tissue development. As is shown in this review, polysaccharide hydrogels, and in particular in situ forming ones, are materials with a high application potential in regenerative medicine.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.carbpol.2011.09.069</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-0983-4557</orcidid></addata></record> |
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| ispartof | Carbohydrate polymers, 2012-01, Vol.87 (2), p.1013-1019 |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Applied sciences Biological and medical sciences Cell delivery Chemical Sciences Exact sciences and technology General pharmacology hydrocolloids Hydrogels In situ forming Material chemistry Medical sciences medicine Natural polymers Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments phenotype Physicochemistry of polymers Polymers Polysaccharides Regenerative medicine Starch and polysaccharides stem cells Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments |
| title | In situ forming polysaccharide-based 3D-hydrogels for cell delivery in regenerative medicine |
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