Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes

Phenobarbital (PB) alters expression of numerous hepatic genes, including genes of cytochrome P450 2B1 and 2B2 (CYP2B). However, the intracellular mechanisms remain to be fully elucidated. The present study investigated the involvement of mitogen-activated protein kinases (MAPKs) in rat hepatocytes...

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Veröffentlicht in:	Toxicology letters 2006-02, Vol.161 (1), p.61-72
Hauptverfasser:	Joannard, Florence, Rissel, Mary, Gilot, David, Anderson, Alan, Orfila-Lefeuvre, Luz, Guillouzo, André, Atfi, Azzedine, Lagadic-Gossmann, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Butadienes Butadienes - pharmacology Cells, Cultured Cytochrome P-450 CYP2B1 Cytochrome P-450 CYP2B1 - antagonists & inhibitors Cytochrome P-450 CYP2B1 - biosynthesis Cytochrome P-450 CYP2B1 - genetics Cytochrome P450 2B Dichlororibofuranosylbenzimidazole Dichlororibofuranosylbenzimidazole - pharmacology Dose-Response Relationship, Drug Drug Synergism Enzyme Activation Enzyme Activation - drug effects Enzyme Inhibitors Enzyme Inhibitors - pharmacology Gene Expression Gene Expression - drug effects Hepatocytes Hepatocytes - cytology Hepatocytes - drug effects Hepatocytes - metabolism Imidazoles Imidazoles - pharmacology Life Sciences Liver Luciferases, Firefly Luciferases, Firefly - genetics Luciferases, Firefly - metabolism Male Medical sciences Mitogen-activated protein kinase Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinase 3 - genetics Mitogen-Activated Protein Kinase 3 - metabolism Mitogen-Activated Protein Kinases Mitogen-Activated Protein Kinases - genetics Mitogen-Activated Protein Kinases - metabolism Mutation Nitriles Nitriles - pharmacology p38 p38 Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phenobarbital Phenobarbital - pharmacology Phosphorylation Phosphorylation - drug effects Pyridines Pyridines - pharmacology Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger RNA, Messenger - genetics RNA, Messenger - metabolism SB-203580 Toxicology Transfection
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