Evolution of the primate β-globin gene region: High rate of variation in CpG dinucleotides and in short repeated sequences between man and chimpanzee

A 5500 base-pair fragment including the β-globin gene downstream from codon 122 and about 4000 base-pairs of its 5′ flanking sequence was cloned from chimpanzee DNA and thoroughly sequenced before being compared with the corresponding human sequence: 88 point differences (83 substitutions and 5 dele...

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