Actin‐independent exclusion of CD95 by PI3K/AKT signalling: Implications for apoptosis

The immune system eliminates infected or transformed cells through the activation of the death receptor CD95. CD95 engagement drives the recruitment of the adaptor protein Fas‐associated death domain protein (FADD), which in turn aggregates and activates initiator caspases‐8 and ‐10. The CD95‐mediat...

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Veröffentlicht in:	European journal of immunology 2011-08, Vol.41 (8), p.2368-2378
Hauptverfasser:	Pizon, Mathieu, Rampanarivo, Hariniaina, Tauzin, Sébastien, Chaigne‐Delalande, Benjamin, Daburon, Sophie, Castroviejo, Michel, Moreau, Patrick, Moreau, Jean‐François, Legembre, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins Actins - metabolism Akt Androstadienes Androstadienes - pharmacology Antigens, CD95 Apoptosis Apoptosis - drug effects Blotting, Western Caspases Caspases - metabolism CD95 Cell Line Cell Line, Tumor Cell Membrane Cell Membrane - metabolism Chromones Chromones - pharmacology Fas Ligand Protein Fas Ligand Protein - metabolism fas Receptor - metabolism Fas-Associated Death Domain Protein Fas-Associated Death Domain Protein - metabolism Flow Cytometry Humans Immunology Jurkat Cells Life Sciences Lipid rafts Lipids Membrane Microdomains Membrane Microdomains - metabolism Morpholines Morpholines - pharmacology Multiprotein Complexes Multiprotein Complexes - metabolism Mutation Phosphatidylinositol 3-Kinases Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism PI3K Protein Kinase Inhibitors Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Signal Transduction
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