Ultraviolet-B irradiation induces epidermal up-regulation of heparanase expression and activity

► Heparan sulfate proteoglycans (HSPG) are crucial for skin integrity. ► They were shown to decrease in aging skin. ► We demonstrate that heparanase mRNA level and enzymatic activity are up-regulated after UV-B irradiation of keratinocytes. ► We suggest that the resulting heparin–sulfate degradation...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2012-01, Vol.106 (5), p.107-112
Hauptverfasser:	Kurdykowski, Sandrine, Mine, Solène, Bardey, Vincent, Danoux, Louis, Jeanmaire, Christine, Pauly, Gilles, Brabencova, Eva, Wegrowski, Yanusz, Maquart, François-Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion Cell Line cell membranes cell proliferation dose response enzymatic activity enzyme activity Epidermis Epidermis - radiation effects Extracellular matrix fluorescent antibody technique gene expression Glucuronidase - genetics Glucuronidase - metabolism Heparan sulfate Heparanase Humans irradiation Keratinocytes Keratinocytes - radiation effects messenger RNA photobiology photochemistry protein synthesis proteoglycans quantitative polymerase chain reaction RNA, Messenger - metabolism Time Factors ultraviolet radiation Ultraviolet Rays Up-Regulation UV-B
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