Deregulation of anti-Mullerian hormone/BMP and transforming growth factor- pathways in Leydig cell lesions developed in male heterozygous multiple endocrine neoplasia type 1 mutant mice

Multiple endocrine neoplasia type 1 (MEN1) results from the mutation of the predisposing gene, MEN1. Heterozygous Men1 mutant mice previously generated by several laboratories, including ours, mimic largely MEN1 pathology. Interestingly, our heterozygous Men1 mutant mice exhibit not only the endocri...

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Veröffentlicht in:	Endocrine-related cancer 2008-03, Vol.15 (1), p.217-227
Hauptverfasser:	Hussein, N., Lu, J., Casse, H., Fontaniere, S., Morera, A.-M., Guittot, S. M., Calender, A., Di Clemente, N., Zhang, C. X
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Mullerian Hormone/metabolism Blotting, Northern Blotting, Western Bone Morphogenetic Proteins/metabolism Cyclin-Dependent Kinase Inhibitor p18/metabolism Cyclin-Dependent Kinase Inhibitor p27/metabolism Endocrinology and metabolism Heterozygote Human health and pathology Immunoenzyme Techniques Immunoprecipitation Leydig Cell Tumor/metabolism Leydig Cell Tumor/pathology Life Sciences Luciferases/metabolism Male Mice Mice, Knockout Multiple Endocrine Neoplasia Type 1/metabolism Multiple Endocrine Neoplasia Type 1/pathology Plasmids Proto-Oncogene Proteins/metabolism Receptors, Peptide/metabolism Receptors, Transforming Growth Factor beta/metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger/genetics RNA, Messenger/metabolism Smad Proteins/metabolism Transforming Growth Factor beta/metabolism
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