Cis-4-methylsphingosine is a sphingosine-1-phosphate receptor modulator

Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P 1–5, that play important roles e.g. in the cardiovascular and immune systems. A S1P receptor modulating drug, FTY720 (fingolimod), has been effective in phase III clinical trials for multiple scl...

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Veröffentlicht in:	Biochemical pharmacology 2011-03, Vol.81 (5), p.617-625
Hauptverfasser:	ter Braak, Michael, Claas, Ralf Frederik, Hegen, Bianca, Labocha, Sandra, Ferreirós, Nerea, Pfeilschifter, Josef, Huwiler, Andrea, van Echten-Deckert, Gerhild, Meyer zu Heringdorf, Dagmar
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Biological and medical sciences Calcium - metabolism clinical trials drugs Fingolimod Hydrochloride FTY720 G-protein coupled receptors GPCR HEK293 Cells Humans Lysophospholipid receptors Lysophospholipids - pharmacology Medical sciences metabolites Pharmacology. Drug treatments Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - biosynthesis Propylene Glycols - pharmacology Receptors, Lysosphingolipid - agonists sclerosis sphingosine Sphingosine - analogs & derivatives Sphingosine - metabolism Sphingosine - pharmacology Sphingosine kinase Sphingosine-1-phosphate Stereoisomerism
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