Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype
The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pum...
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| Veröffentlicht in: | International journal of antimicrobial agents 2011-02, Vol.37 (2), p.156-161 |
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| creator | Kuete, V Alibert-Franco, S Eyong, K.O Ngameni, B Folefoc, G.N Nguemeving, J.R Tangmouo, J.G Fotso, G.W Komguem, J Ouahouo, B.M.W Bolla, J.-M Chevalier, J Ngadjui, B.T Nkengfack, A.E Pagès, J.-M |
| description | The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB–TolC (Enterobacteriaceae) and MexAB–OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products. |
| doi_str_mv | 10.1016/j.ijantimicag.2010.10.020 |
| format | Article |
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The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB–TolC (Enterobacteriaceae) and MexAB–OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2010.10.020</identifier><identifier>PMID: 21163632</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alkaloids ; Alkaloids - metabolism ; Alkaloids - pharmacology ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacology ; anti-infective agents ; Antibacterial activities ; antibacterial properties ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Biological Products - chemistry ; Biological Products - pharmacology ; Biological Transport ; coumarin ; Drug Resistance, Multiple, Bacterial ; Efflux pump inhibitor ; Enterobacteriaceae ; flavonoids ; Gram-negative bacteria ; Gram-Negative Bacteria - drug effects ; Humans ; Infectious Disease ; Medical sciences ; Membrane Transport Proteins - metabolism ; Multidrug resistance ; multiple drug resistance ; Pharmacology. Drug treatments ; phenolic compounds ; Phenolics ; Phenols - metabolism ; Phenols - pharmacology ; phenotype ; plumbagin ; Pseudomonas aeruginosa ; Terpenes - metabolism ; Terpenes - pharmacology ; Terpenoids ; transporters ; xanthone</subject><ispartof>International journal of antimicrobial agents, 2011-02, Vol.37 (2), p.156-161</ispartof><rights>Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2010 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c626t-ff6d873221ab9a7e0a2755b7bd82732bef9a6f1a4713bba5245557a7a1ea46753</citedby><cites>FETCH-LOGICAL-c626t-ff6d873221ab9a7e0a2755b7bd82732bef9a6f1a4713bba5245557a7a1ea46753</cites><orcidid>0000-0001-8546-6149</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0924857910004930$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23795301$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21163632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00659899$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuete, V</creatorcontrib><creatorcontrib>Alibert-Franco, S</creatorcontrib><creatorcontrib>Eyong, K.O</creatorcontrib><creatorcontrib>Ngameni, B</creatorcontrib><creatorcontrib>Folefoc, G.N</creatorcontrib><creatorcontrib>Nguemeving, J.R</creatorcontrib><creatorcontrib>Tangmouo, J.G</creatorcontrib><creatorcontrib>Fotso, G.W</creatorcontrib><creatorcontrib>Komguem, J</creatorcontrib><creatorcontrib>Ouahouo, B.M.W</creatorcontrib><creatorcontrib>Bolla, J.-M</creatorcontrib><creatorcontrib>Chevalier, J</creatorcontrib><creatorcontrib>Ngadjui, B.T</creatorcontrib><creatorcontrib>Nkengfack, A.E</creatorcontrib><creatorcontrib>Pagès, J.-M</creatorcontrib><title>Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>The present study assessed the antimicrobial activities of various natural products belonging to the terpenoids, alkaloids and phenolics against a collection of Gram-negative multidrug-resistant (MDR) bacteria. The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB–TolC (Enterobacteriaceae) and MexAB–OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products.</description><subject>Alkaloids</subject><subject>Alkaloids - metabolism</subject><subject>Alkaloids - pharmacology</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>anti-infective agents</subject><subject>Antibacterial activities</subject><subject>antibacterial properties</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Biological Products - chemistry</subject><subject>Biological Products - pharmacology</subject><subject>Biological Transport</subject><subject>coumarin</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Efflux pump inhibitor</subject><subject>Enterobacteriaceae</subject><subject>flavonoids</subject><subject>Gram-negative bacteria</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Medical sciences</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Multidrug resistance</subject><subject>multiple drug resistance</subject><subject>Pharmacology. Drug treatments</subject><subject>phenolic compounds</subject><subject>Phenolics</subject><subject>Phenols - metabolism</subject><subject>Phenols - pharmacology</subject><subject>phenotype</subject><subject>plumbagin</subject><subject>Pseudomonas aeruginosa</subject><subject>Terpenes - metabolism</subject><subject>Terpenes - pharmacology</subject><subject>Terpenoids</subject><subject>transporters</subject><subject>xanthone</subject><issn>0924-8579</issn><issn>1872-7913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktv1DAUhSMEokPhL0BYIMQigx9xHG8qjUZAkUZiUbq2bpybqdO8sJ0R8-9xmGlBrFjZuv7uucc-TpK3lKwpocXHdm1bGILtrYH9mpHf9TVh5EmyoqVkmVSUP01WRLE8K4VUF8kL71tCqOC5eJ5cMEoLXnC2Su43UacCE9BZ6NK4sQcbjunYpH7sMR0gzC4eTG6sZxN8Cnuwgw_pQ0-KPyeH3tthn0Laz12wtZv3WaxZH6LLdLrDYQzHCV8mzxroPL46r5fJ7edP37fX2e7bl6_bzS4zBStC1jRFXUrOGIVKgUQCTApRyaouWSxX2CgoGgq5pLyqQLBcCCFBAkXICyn4ZfLhpHsHnZ6c7cEd9QhWX292eqkRUghVKnWgkX1_YuMFf8zog-6tN9h1MOA4e13mPKeMq0VVnUjjRu8dNo_SlOglFt3qv2LRSyzLUYwl9r4-T5mrHuvHzoccIvDuDIA30DUOBmP9H47L6IAsdt-cuAZGDXsXmdubOEnEbEvG-TJqeyIwvvDBotPeWBwM1tahCboe7X8ZvvpHxXR2iFh3j0f07Ti7IUaoqfZME32z_LTlo1FCSK6ijV8jC9CT</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Kuete, V</creator><creator>Alibert-Franco, S</creator><creator>Eyong, K.O</creator><creator>Ngameni, B</creator><creator>Folefoc, G.N</creator><creator>Nguemeving, J.R</creator><creator>Tangmouo, J.G</creator><creator>Fotso, G.W</creator><creator>Komguem, J</creator><creator>Ouahouo, B.M.W</creator><creator>Bolla, J.-M</creator><creator>Chevalier, J</creator><creator>Ngadjui, B.T</creator><creator>Nkengfack, A.E</creator><creator>Pagès, J.-M</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0001-8546-6149</orcidid></search><sort><creationdate>20110201</creationdate><title>Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype</title><author>Kuete, V ; Alibert-Franco, S ; Eyong, K.O ; Ngameni, B ; Folefoc, G.N ; Nguemeving, J.R ; Tangmouo, J.G ; Fotso, G.W ; Komguem, J ; Ouahouo, B.M.W ; Bolla, J.-M ; Chevalier, J ; Ngadjui, B.T ; Nkengfack, A.E ; Pagès, J.-M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c626t-ff6d873221ab9a7e0a2755b7bd82732bef9a6f1a4713bba5245557a7a1ea46753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Alkaloids</topic><topic>Alkaloids - metabolism</topic><topic>Alkaloids - pharmacology</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>anti-infective agents</topic><topic>Antibacterial activities</topic><topic>antibacterial properties</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Biological Products - chemistry</topic><topic>Biological Products - pharmacology</topic><topic>Biological Transport</topic><topic>coumarin</topic><topic>Drug Resistance, Multiple, Bacterial</topic><topic>Efflux pump inhibitor</topic><topic>Enterobacteriaceae</topic><topic>flavonoids</topic><topic>Gram-negative bacteria</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Medical sciences</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>Multidrug resistance</topic><topic>multiple drug resistance</topic><topic>Pharmacology. 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The results demonstrated that most of the compounds were extruded by bacterial efflux pumps. In the presence of the efflux pump inhibitor phenylalanine arginine β-naphthylamide (PAβN), the activities of laurentixanthone B (xanthone), plumbagin (naphthoquinone), 4-hydroxylonchocarpin (flavonoid) and MAB3 (coumarin) increased significantly against all studied MDR bacteria. Laurentixanthone B, 4-hydroxylonchocarpin and MAB3 contained the same pharmacophoric moiety as plumbagin. This study indicates that the AcrAB–TolC (Enterobacteriaceae) and MexAB–OprM (Pseudomonas aeruginosa) efflux pumps are involved in resistance of Gram-negative bacteria to most of the natural products.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21163632</pmid><doi>10.1016/j.ijantimicag.2010.10.020</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8546-6149</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of antimicrobial agents, 2011-02, Vol.37 (2), p.156-161 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alkaloids Alkaloids - metabolism Alkaloids - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology anti-infective agents Antibacterial activities antibacterial properties Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Biological Products - chemistry Biological Products - pharmacology Biological Transport coumarin Drug Resistance, Multiple, Bacterial Efflux pump inhibitor Enterobacteriaceae flavonoids Gram-negative bacteria Gram-Negative Bacteria - drug effects Humans Infectious Disease Medical sciences Membrane Transport Proteins - metabolism Multidrug resistance multiple drug resistance Pharmacology. Drug treatments phenolic compounds Phenolics Phenols - metabolism Phenols - pharmacology phenotype plumbagin Pseudomonas aeruginosa Terpenes - metabolism Terpenes - pharmacology Terpenoids transporters xanthone |
| title | Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype |
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