A simple method to achieve high doxorubicin loading in biodegradable polymersomes

Doxorubicin (Dox), an anthracycline anticancer drug, was successfully incorporated into block copolymer vesicles of poly(trimethylene carbonate)- b-poly( l-glutamic acid) (PTMC- b-PGA) by a solvent-displacement (nanoprecipitation) method. pH conditions were shown to have a strong influence on loadin...

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Veröffentlicht in:	Journal of controlled release 2010-11, Vol.147 (3), p.428-435
Hauptverfasser:	Sanson, Charles, Schatz, Christophe, Le Meins, Jean-François, Soum, Alain, Thévenot, Julie, Garanger, Elisabeth, Lecommandoux, Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemistry Biological and medical sciences Block copolymer Chemical Precipitation Chemical Sciences Chemistry, Pharmaceutical Controlled release Delayed-Action Preparations Dioxanes - chemistry Doxorubicin Doxorubicin - chemistry Drug Carriers Drug Compounding Drug delivery Drug Stability General pharmacology Hydrogen-Ion Concentration Kinetics Medical sciences Models, Chemical Nanotechnology Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyglutamic Acid - chemistry Polymers Polymers - chemistry Polymersome Solubility Technology, Pharmaceutical - methods Temperature Vesicle
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