Transition-Metal-Catalyzed Uninterrupted Four-Step Sequence to Access Trisubstituted Isoxazoles

Transition-Metal-Catalyzed Uninterrupted Four-Step Sequence to Access Trisubstituted Isoxazoles

We describe herein a novel uninterrupted four-step sequence to access trisubstituted isoxazoles from readily available propargylic alcohols using sequentially iron and palladium catalytic systems. The advantages of such a strategy are illustrated by the high overall yields and the time-saving proced...

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Veröffentlicht in:Organic letters 2011-12, Vol.13 (24), p.6418-6421
Hauptverfasser: Gayon, Eric, Quinonero, Ophélie, Lemouzy, Sébastien, Vrancken, Emmanuel, Campagne, Jean-Marc
Format: Artikel
Sprache:eng
Schlagworte:
Chemical Sciences
Cheminformatics
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Zusammenfassung:We describe herein a novel uninterrupted four-step sequence to access trisubstituted isoxazoles from readily available propargylic alcohols using sequentially iron and palladium catalytic systems. The advantages of such a strategy are illustrated by the high overall yields and the time-saving procedure that are reported.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202719n