Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk
Summary A genome‐wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case‐control datasets from Poland, UK an...
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| Veröffentlicht in: | British journal of haematology 2011-07, Vol.154 (2), p.229-233 |
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| creator | Crowther‐Swanepoel, Dalemari Di Bernardo, Maria Chiara Jamroziak, Krzysztof Karabon, Lidia Frydecka, Irena Deaglio, Silvia D’Arena, Giovanni Rossi, Davide Gaidano, Gianluca Olver, Bianca Lloyd, Amy Broderick, Peter Laurenti, Luca Szemraj‐Rogucka, Zofia Robak, Tadeusz Catovsky, Daniel Houlston, Richard S. |
| description | Summary
A genome‐wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case‐control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined = 1·10 × 10−7 and 1·30 × 10−5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development. |
| doi_str_mv | 10.1111/j.1365-2141.2011.08706.x |
| format | Article |
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A genome‐wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case‐control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined = 1·10 × 10−7 and 1·30 × 10−5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2011.08706.x</identifier><identifier>PMID: 21554262</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aged ; Biological and medical sciences ; Case-Control Studies ; chromosome 15 ; chromosome 18 ; Chromosomes, Human, Pair 15 - genetics ; Chromosomes, Human, Pair 18 - genetics ; Chronic lymphatic leukemia ; chronic lymphocytic leukaemia ; common variant ; CPEB1 ; Data processing ; Female ; Genetic diversity ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Hematologic and hematopoietic diseases ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Single Nucleotide ; risk</subject><ispartof>British journal of haematology, 2011-07, Vol.154 (2), p.229-233</ispartof><rights>2011 Blackwell Publishing Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2011 Blackwell Publishing Ltd.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5146-f90d4aaabec1b6cc00b77309a6c1bf9ee761bd4961ddfef5b0d44e7dc0d1f42c3</citedby><cites>FETCH-LOGICAL-c5146-f90d4aaabec1b6cc00b77309a6c1bf9ee761bd4961ddfef5b0d44e7dc0d1f42c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2011.08706.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2011.08706.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24338957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21554262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00639394$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Crowther‐Swanepoel, Dalemari</creatorcontrib><creatorcontrib>Di Bernardo, Maria Chiara</creatorcontrib><creatorcontrib>Jamroziak, Krzysztof</creatorcontrib><creatorcontrib>Karabon, Lidia</creatorcontrib><creatorcontrib>Frydecka, Irena</creatorcontrib><creatorcontrib>Deaglio, Silvia</creatorcontrib><creatorcontrib>D’Arena, Giovanni</creatorcontrib><creatorcontrib>Rossi, Davide</creatorcontrib><creatorcontrib>Gaidano, Gianluca</creatorcontrib><creatorcontrib>Olver, Bianca</creatorcontrib><creatorcontrib>Lloyd, Amy</creatorcontrib><creatorcontrib>Broderick, Peter</creatorcontrib><creatorcontrib>Laurenti, Luca</creatorcontrib><creatorcontrib>Szemraj‐Rogucka, Zofia</creatorcontrib><creatorcontrib>Robak, Tadeusz</creatorcontrib><creatorcontrib>Catovsky, Daniel</creatorcontrib><creatorcontrib>Houlston, Richard S.</creatorcontrib><title>Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
A genome‐wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case‐control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined = 1·10 × 10−7 and 1·30 × 10−5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>chromosome 15</subject><subject>chromosome 18</subject><subject>Chromosomes, Human, Pair 15 - genetics</subject><subject>Chromosomes, Human, Pair 18 - genetics</subject><subject>Chronic lymphatic leukemia</subject><subject>chronic lymphocytic leukaemia</subject><subject>common variant</subject><subject>CPEB1</subject><subject>Data processing</subject><subject>Female</subject><subject>Genetic diversity</subject><subject>Genetic Predisposition to Disease</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>risk</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU2P0zAQhi0EYrsLfwHlghCHhBnHH_GBw27FUlAlhARny3Ec6m4-una6bP89Di3lCL7YHj_veKSHkAyhwLTebQssBc8pMiwoIBZQSRDF4xOyOD88JQsAkDkCqy7IZYxbACyB43NyQZFzRgVdkK_Lse_HIfvhBjd5mz2Y4M3kU8VMGfJ7ygua-X5n7BSzVLWbMA6J6w79bjPaw5zp3P7OuN6bLPh494I8a00X3cvTfkW-3374tlzl6y8fPy2v17nlyETeKmiYMaZ2FmthLUAtZQnKiHRvlXNSYN0wJbBpWtfyOuHMycZCgy2jtrwib499N6bTu-B7Ew56NF6vrtd6rgGIUpWKPWBi3xzZXRjv9y5OuvfRuq4zgxv3USuQKFCxf5NVxaikFbJEVkfShjHG4NrzEAh6tqS3epahZxl6tqR_W9KPKfrq9Mm-7l1zDv7RkoDXJ8BEa7o2mMH6-JdjZVkpLhP3_sj99J07_PcA-ubzaj6VvwA_LqxE</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Crowther‐Swanepoel, Dalemari</creator><creator>Di Bernardo, Maria Chiara</creator><creator>Jamroziak, Krzysztof</creator><creator>Karabon, Lidia</creator><creator>Frydecka, Irena</creator><creator>Deaglio, Silvia</creator><creator>D’Arena, Giovanni</creator><creator>Rossi, Davide</creator><creator>Gaidano, Gianluca</creator><creator>Olver, Bianca</creator><creator>Lloyd, Amy</creator><creator>Broderick, Peter</creator><creator>Laurenti, Luca</creator><creator>Szemraj‐Rogucka, Zofia</creator><creator>Robak, Tadeusz</creator><creator>Catovsky, Daniel</creator><creator>Houlston, Richard S.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>201107</creationdate><title>Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk</title><author>Crowther‐Swanepoel, Dalemari ; Di Bernardo, Maria Chiara ; Jamroziak, Krzysztof ; Karabon, Lidia ; Frydecka, Irena ; Deaglio, Silvia ; D’Arena, Giovanni ; Rossi, Davide ; Gaidano, Gianluca ; Olver, Bianca ; Lloyd, Amy ; Broderick, Peter ; Laurenti, Luca ; Szemraj‐Rogucka, Zofia ; Robak, Tadeusz ; Catovsky, Daniel ; Houlston, Richard S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5146-f90d4aaabec1b6cc00b77309a6c1bf9ee761bd4961ddfef5b0d44e7dc0d1f42c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>chromosome 15</topic><topic>chromosome 18</topic><topic>Chromosomes, Human, Pair 15 - genetics</topic><topic>Chromosomes, Human, Pair 18 - genetics</topic><topic>Chronic lymphatic leukemia</topic><topic>chronic lymphocytic leukaemia</topic><topic>common variant</topic><topic>CPEB1</topic><topic>Data processing</topic><topic>Female</topic><topic>Genetic diversity</topic><topic>Genetic Predisposition to Disease</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>Leukemias. 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A genome‐wide association study of chronic lymphocytic leukaemia (CLL) suggested that common variants at 15q25.2 (rs783540) and 18q21.1 (rs1036935) influence CLL. To validate these associations and explore their relationship with CLL risk we genotyped case‐control datasets from Poland, UK and Italy totalling 1428 cases and 1920 controls. Combined data from these and previously genotyped series (2503 cases and 5789 controls) provided evidence for an association between 15q25.2 and 18q21.1 loci and CLL risk (Pcombined = 1·10 × 10−7 and 1·30 × 10−5 respectively). These data provide further evidence for the involvement of common genetic variants in CLL risk and insight into the biological basis of disease development.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21554262</pmid><doi>10.1111/j.1365-2141.2011.08706.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Case-Control Studies chromosome 15 chromosome 18 Chromosomes, Human, Pair 15 - genetics Chromosomes, Human, Pair 18 - genetics Chronic lymphatic leukemia chronic lymphocytic leukaemia common variant CPEB1 Data processing Female Genetic diversity Genetic Predisposition to Disease Genome-Wide Association Study Genotype Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Polymorphism, Single Nucleotide risk |
| title | Common genetic variation at 15q25.2 impacts on chronic lymphocytic leukaemia risk |
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