The role of 11β-hydroxysteroid dehydrogenase type 2 in human hypertension

Cortisol and aldosterone have the same in vitro affinity for the mineralocorticoid receptor (MR), although in vivo only aldosterone acts as a physiologic agonist of the MR, despite circulating levels of cortisol in humans and corticosterone in rodents being three orders of magnitude higher than aldo...

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Veröffentlicht in:	Biochimica et biophysica acta 2010-12, Vol.1802 (12), p.1178-1187
1. Verfasser:	Ferrari, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism 11β-hydroxysteroid dehydrogenase Aldosterone Aldosterone - genetics Aldosterone - metabolism Animals Blood Pressure Colon - metabolism Corticosterone - genetics Corticosterone - metabolism Cortisol Distal renal tubule Glucocorticoid Humans Hydrocortisone - genetics Hydrocortisone - metabolism Hypertension - genetics Hypertension - metabolism Kidney - metabolism Microsatellite Repeats - genetics Mineralocorticoid Receptors, Mineralocorticoid - genetics Receptors, Mineralocorticoid - metabolism Rodentia Sodium Sodium - metabolism
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