Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes
As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes...
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| Veröffentlicht in: | ACS nano 2011-11, Vol.5 (11), p.9264-9270 |
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| creator | Serag, Maged F Kaji, Noritada Venturelli, Enrica Okamoto, Yukihiro Terasaka, Kazuyoshi Tokeshi, Manabu Mizukami, Hajime Braeckmans, Kevin Bianco, Alberto Baba, Yoshinobu |
| description | As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology. |
| doi_str_mv | 10.1021/nn2035654 |
| format | Article |
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Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.</description><subject>Access control</subject><subject>Biological Transport</subject><subject>Carbon nanotubes</subject><subject>Carriers</subject><subject>Catharanthus - cytology</subject><subject>Cellular</subject><subject>Chemical Sciences</subject><subject>Exocytosis</subject><subject>Fluorescence Recovery After Photobleaching</subject><subject>Fluorescent Dyes - metabolism</subject><subject>Intracellular Space - metabolism</subject><subject>Medicinal Chemistry</subject><subject>Nanostructure</subject><subject>Nanotubes, Carbon</subject><subject>Single wall carbon nanotubes</subject><subject>Strategy</subject><subject>Surface Properties</subject><subject>Toxicity</subject><subject>Uptakes</subject><subject>Vacuoles - metabolism</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEQhoMotlYP_gHZi6CHarL52h7Laq1QrKCCt5CkCW7JbmqyEfz3bmldL15mhuGZB-YF4BzBGwRzdNs0OcSUUXIAhmiC2RgW7P2wnykagJMY1xBSXnB2DAY5mhSI0ckQLGep0W3lG-myZydb60OddSUrfdMG75xZZS9JaeNccjJkd1VsQ6XS9iTzNitlUN30JBvfJmXiKTiy0kVztu8j8Da7fy3n48Xy4bGcLsaSEN6OFVfK6oLxCcYGY6SV1oXBxmjKzIoibG1ujCWWMV4wRgihiGOEcsxk94PBI3C9835IJzahqmX4Fl5WYj5diO0OQoZJTvgX6tirHbsJ_jOZ2Iq6ituPZGN8igJxlkNKOUR_Wh18jMHY3o2g2GYt-qw79mKvTao2q578DbcDLneA1FGsfQpdyPEf0Q_IKoRo</recordid><startdate>20111122</startdate><enddate>20111122</enddate><creator>Serag, Maged F</creator><creator>Kaji, Noritada</creator><creator>Venturelli, Enrica</creator><creator>Okamoto, Yukihiro</creator><creator>Terasaka, Kazuyoshi</creator><creator>Tokeshi, Manabu</creator><creator>Mizukami, Hajime</creator><creator>Braeckmans, Kevin</creator><creator>Bianco, Alberto</creator><creator>Baba, Yoshinobu</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-1090-296X</orcidid></search><sort><creationdate>20111122</creationdate><title>Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes</title><author>Serag, Maged F ; Kaji, Noritada ; Venturelli, Enrica ; Okamoto, Yukihiro ; Terasaka, Kazuyoshi ; Tokeshi, Manabu ; Mizukami, Hajime ; Braeckmans, Kevin ; Bianco, Alberto ; Baba, Yoshinobu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a447t-b7bbfc867933e331cbcc8e3eec56ed513ff2eef4f667866444517311236a787e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Access control</topic><topic>Biological Transport</topic><topic>Carbon nanotubes</topic><topic>Carriers</topic><topic>Catharanthus - cytology</topic><topic>Cellular</topic><topic>Chemical Sciences</topic><topic>Exocytosis</topic><topic>Fluorescence Recovery After Photobleaching</topic><topic>Fluorescent Dyes - metabolism</topic><topic>Intracellular Space - metabolism</topic><topic>Medicinal Chemistry</topic><topic>Nanostructure</topic><topic>Nanotubes, Carbon</topic><topic>Single wall carbon nanotubes</topic><topic>Strategy</topic><topic>Surface Properties</topic><topic>Toxicity</topic><topic>Uptakes</topic><topic>Vacuoles - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serag, Maged F</creatorcontrib><creatorcontrib>Kaji, Noritada</creatorcontrib><creatorcontrib>Venturelli, Enrica</creatorcontrib><creatorcontrib>Okamoto, Yukihiro</creatorcontrib><creatorcontrib>Terasaka, Kazuyoshi</creatorcontrib><creatorcontrib>Tokeshi, Manabu</creatorcontrib><creatorcontrib>Mizukami, Hajime</creatorcontrib><creatorcontrib>Braeckmans, Kevin</creatorcontrib><creatorcontrib>Bianco, Alberto</creatorcontrib><creatorcontrib>Baba, Yoshinobu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serag, Maged F</au><au>Kaji, Noritada</au><au>Venturelli, Enrica</au><au>Okamoto, Yukihiro</au><au>Terasaka, Kazuyoshi</au><au>Tokeshi, Manabu</au><au>Mizukami, Hajime</au><au>Braeckmans, Kevin</au><au>Bianco, Alberto</au><au>Baba, Yoshinobu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2011-11-22</date><risdate>2011</risdate><volume>5</volume><issue>11</issue><spage>9264</spage><epage>9270</epage><pages>9264-9270</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>As nanoparticles can cross different cellular barriers and access different tissues, control of their uptake and cellular fate presents a functional approach that will be broadly applicable to nanoscale technologies in cell biology. Here we show that the trafficking of single-walled carbon nanotubes (SWCNTs) through various subcellular membranes of the plant cell is facilitated or inhibited by attaching a suitable functional tag and controlling medium components. This enables a unique control over the uptake and the subcellular distribution of SWCNTs and provides a key strategy to promote their cellular elimination to minimize toxicity. Our results also demonstrate that SWCNTs are involved in a carrier-mediated transport (CMT) inside cells; this is a phenomenon that scientists could use to obtain novel molecular insights into CMT, with the potential translation to advances in subcellular nanobiology.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>21981659</pmid><doi>10.1021/nn2035654</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1090-296X</orcidid></addata></record> |
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| subjects | Access control Biological Transport Carbon nanotubes Carriers Catharanthus - cytology Cellular Chemical Sciences Exocytosis Fluorescence Recovery After Photobleaching Fluorescent Dyes - metabolism Intracellular Space - metabolism Medicinal Chemistry Nanostructure Nanotubes, Carbon Single wall carbon nanotubes Strategy Surface Properties Toxicity Uptakes Vacuoles - metabolism |
| title | Functional Platform for Controlled Subcellular Distribution of Carbon Nanotubes |
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