Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis
ObjectivesReports of increased amyotrophic lateral sclerosis (ALS) with hyperlipidaemia and elevated plasma homocysteine levels as well as cigarette-smoking and polymorphisms in angiogenic genes suggest a role for altered vascular homeostasis in ALS pathogenesis. The authors assessed the association...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2011-06, Vol.82 (6), p.638-642 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Sutedja, N A van der Schouw, Y T Fischer, K Sizoo, E M Huisman, M H B Veldink, J H Van den Berg, L H |
| description | ObjectivesReports of increased amyotrophic lateral sclerosis (ALS) with hyperlipidaemia and elevated plasma homocysteine levels as well as cigarette-smoking and polymorphisms in angiogenic genes suggest a role for altered vascular homeostasis in ALS pathogenesis. The authors assessed the association between vascular risk factors and ALS.MethodsTraditional cardiovascular risk factors (smoking, hypertension, hypercholesterolaemia, diabetes and body mass index (BMI)) and cardiovascular disease prior to ALS onset established by a questionnaire were compared in 334 patients and 538 age- and sex-matched controls. Biochemical assessments (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hs-CRP, and homocysteine) at diagnosis were measured in blood samples of 303 patients with ALS and compared with prospectively collected data from 2100 population-based controls.ResultsPatients with ALS used cholesterol-lowering agents less frequently (OR=0.6, p=0.008) and had a lower BMI (OR=0.9, p=0.001), a lower LDL/HDL ratio (women: OR=0.5, p |
| doi_str_mv | 10.1136/jnnp.2010.236752 |
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| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_00629465v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>904470928</sourcerecordid><originalsourceid>FETCH-LOGICAL-b508t-e302f167ade549bad394cc9a8e93049cd14b2a0f0683f5e512b51e4924986be23</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS0EotPCnhWKxAIhlHL9jL0sI0pBoyLEc2c5jqPx1EmmdtLSf4-jlFmwqTeW7_3Offgg9ALDKcZUvNv1_f6UQH4SKipOHqEVZkKWlMLvx2gFQEhJgcMROk5pB_OR6ik6IphVGEu2Ql_fu9613noTihuT7BRMLKJPV8U-Dq0PrvCpMCkNmRhdU9z6cVuY7m4Y47DfeluEHI5ZnGxwcUg-PUNPWhOSe35_n6Af5x--ry_KzZePn9Znm7LmIMfSUSAtFpVpHGeqNg1VzFplpFMUmLINZjUx0IKQtOWOY1Jz7JgiTElRO0JP0Jul7tYEvY--M_FOD8bri7ONnmMAgigm-A3O7OuFzUtdTy6NuvPJuhBM74YpaQWMVaCIfJCUggvFqeCZfPUfuRum2OeVNa4kJkxQNneGhbL5c1J07WFUDHr2UM8e6tlDvXiYJS_vC09155qD4J9pGSgXwKfR_TnkTbzSoqIV15c_1_pcUPGZX_7S3zL_duHrbvdw-79EarL4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781246341</pqid></control><display><type>article</type><title>Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Sutedja, N A ; van der Schouw, Y T ; Fischer, K ; Sizoo, E M ; Huisman, M H B ; Veldink, J H ; Van den Berg, L H</creator><creatorcontrib>Sutedja, N A ; van der Schouw, Y T ; Fischer, K ; Sizoo, E M ; Huisman, M H B ; Veldink, J H ; Van den Berg, L H</creatorcontrib><description>ObjectivesReports of increased amyotrophic lateral sclerosis (ALS) with hyperlipidaemia and elevated plasma homocysteine levels as well as cigarette-smoking and polymorphisms in angiogenic genes suggest a role for altered vascular homeostasis in ALS pathogenesis. The authors assessed the association between vascular risk factors and ALS.MethodsTraditional cardiovascular risk factors (smoking, hypertension, hypercholesterolaemia, diabetes and body mass index (BMI)) and cardiovascular disease prior to ALS onset established by a questionnaire were compared in 334 patients and 538 age- and sex-matched controls. Biochemical assessments (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hs-CRP, and homocysteine) at diagnosis were measured in blood samples of 303 patients with ALS and compared with prospectively collected data from 2100 population-based controls.ResultsPatients with ALS used cholesterol-lowering agents less frequently (OR=0.6, p=0.008) and had a lower BMI (OR=0.9, p=0.001), a lower LDL/HDL ratio (women: OR=0.5, p<0.001; men: OR=0.4, p<0.001) and lower homocysteine levels (women: OR=0.9, p=0.02; men: OR=0.9, p<0.001). The mean LDL and TC levels were significantly lower among patients with a lower functional vital capacity percentage of predicted (FVC). In the univariate analysis, a higher LDL/HDL ratio correlated with increased survival (HR=0.9, p=0.04); after adjusting for the confounders age, site and FVC, no difference was observed.ConclusionsVascular risk factors, measured clinically and biochemically, were not associated with increased ALS. Instead, patients reported less use of cholesterol-lowering medication and had a lower premorbid BMI and favourable lipid profile—all findings consistent with the hypothesis that a higher metabolic rate plays a role in ALS.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2010.236752</identifier><identifier>PMID: 21471184</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd</publisher><subject>Adult ; Age ; Aged ; Aged, 80 and over ; Alzheimer's disease ; Amyotrophic lateral sclerosis ; Amyotrophic Lateral Sclerosis - blood ; Amyotrophic Lateral Sclerosis - complications ; Amyotrophic Lateral Sclerosis - mortality ; Angina pectoris ; Body Mass Index ; C-Reactive Protein - metabolism ; Cancer ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - complications ; Cholesterol - blood ; Cohort analysis ; Female ; High density lipoprotein ; Homocysteine ; Homocysteine - blood ; Humans ; Hypotheses ; Lipids ; Male ; Middle Aged ; Motor neuron disease ; Patients ; Questionnaires ; Regression analysis ; Risk Factors ; Self Report ; Smoking - adverse effects ; Survival analysis ; Vascular endothelial growth factor ; Women</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2011-06, Vol.82 (6), p.638-642</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b508t-e302f167ade549bad394cc9a8e93049cd14b2a0f0683f5e512b51e4924986be23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/82/6/638.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/82/6/638.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,230,314,776,780,881,3183,23550,27901,27902,77569,77600</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21471184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00629465$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Sutedja, N A</creatorcontrib><creatorcontrib>van der Schouw, Y T</creatorcontrib><creatorcontrib>Fischer, K</creatorcontrib><creatorcontrib>Sizoo, E M</creatorcontrib><creatorcontrib>Huisman, M H B</creatorcontrib><creatorcontrib>Veldink, J H</creatorcontrib><creatorcontrib>Van den Berg, L H</creatorcontrib><title>Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>ObjectivesReports of increased amyotrophic lateral sclerosis (ALS) with hyperlipidaemia and elevated plasma homocysteine levels as well as cigarette-smoking and polymorphisms in angiogenic genes suggest a role for altered vascular homeostasis in ALS pathogenesis. The authors assessed the association between vascular risk factors and ALS.MethodsTraditional cardiovascular risk factors (smoking, hypertension, hypercholesterolaemia, diabetes and body mass index (BMI)) and cardiovascular disease prior to ALS onset established by a questionnaire were compared in 334 patients and 538 age- and sex-matched controls. Biochemical assessments (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hs-CRP, and homocysteine) at diagnosis were measured in blood samples of 303 patients with ALS and compared with prospectively collected data from 2100 population-based controls.ResultsPatients with ALS used cholesterol-lowering agents less frequently (OR=0.6, p=0.008) and had a lower BMI (OR=0.9, p=0.001), a lower LDL/HDL ratio (women: OR=0.5, p<0.001; men: OR=0.4, p<0.001) and lower homocysteine levels (women: OR=0.9, p=0.02; men: OR=0.9, p<0.001). The mean LDL and TC levels were significantly lower among patients with a lower functional vital capacity percentage of predicted (FVC). In the univariate analysis, a higher LDL/HDL ratio correlated with increased survival (HR=0.9, p=0.04); after adjusting for the confounders age, site and FVC, no difference was observed.ConclusionsVascular risk factors, measured clinically and biochemically, were not associated with increased ALS. Instead, patients reported less use of cholesterol-lowering medication and had a lower premorbid BMI and favourable lipid profile—all findings consistent with the hypothesis that a higher metabolic rate plays a role in ALS.</description><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer's disease</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - blood</subject><subject>Amyotrophic Lateral Sclerosis - complications</subject><subject>Amyotrophic Lateral Sclerosis - mortality</subject><subject>Angina pectoris</subject><subject>Body Mass Index</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cancer</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cholesterol - blood</subject><subject>Cohort analysis</subject><subject>Female</subject><subject>High density lipoprotein</subject><subject>Homocysteine</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Lipids</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor neuron disease</subject><subject>Patients</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Self Report</subject><subject>Smoking - adverse effects</subject><subject>Survival analysis</subject><subject>Vascular endothelial growth factor</subject><subject>Women</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkUtv1DAUhS0EotPCnhWKxAIhlHL9jL0sI0pBoyLEc2c5jqPx1EmmdtLSf4-jlFmwqTeW7_3Offgg9ALDKcZUvNv1_f6UQH4SKipOHqEVZkKWlMLvx2gFQEhJgcMROk5pB_OR6ik6IphVGEu2Ql_fu9613noTihuT7BRMLKJPV8U-Dq0PrvCpMCkNmRhdU9z6cVuY7m4Y47DfeluEHI5ZnGxwcUg-PUNPWhOSe35_n6Af5x--ry_KzZePn9Znm7LmIMfSUSAtFpVpHGeqNg1VzFplpFMUmLINZjUx0IKQtOWOY1Jz7JgiTElRO0JP0Jul7tYEvY--M_FOD8bri7ONnmMAgigm-A3O7OuFzUtdTy6NuvPJuhBM74YpaQWMVaCIfJCUggvFqeCZfPUfuRum2OeVNa4kJkxQNneGhbL5c1J07WFUDHr2UM8e6tlDvXiYJS_vC09155qD4J9pGSgXwKfR_TnkTbzSoqIV15c_1_pcUPGZX_7S3zL_duHrbvdw-79EarL4</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Sutedja, N A</creator><creator>van der Schouw, Y T</creator><creator>Fischer, K</creator><creator>Sizoo, E M</creator><creator>Huisman, M H B</creator><creator>Veldink, J H</creator><creator>Van den Berg, L H</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>20110601</creationdate><title>Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis</title><author>Sutedja, N A ; van der Schouw, Y T ; Fischer, K ; Sizoo, E M ; Huisman, M H B ; Veldink, J H ; Van den Berg, L H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b508t-e302f167ade549bad394cc9a8e93049cd14b2a0f0683f5e512b51e4924986be23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer's disease</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - blood</topic><topic>Amyotrophic Lateral Sclerosis - complications</topic><topic>Amyotrophic Lateral Sclerosis - mortality</topic><topic>Angina pectoris</topic><topic>Body Mass Index</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cancer</topic><topic>Cardiovascular Diseases - blood</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cholesterol - blood</topic><topic>Cohort analysis</topic><topic>Female</topic><topic>High density lipoprotein</topic><topic>Homocysteine</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Lipids</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor neuron disease</topic><topic>Patients</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Self Report</topic><topic>Smoking - adverse effects</topic><topic>Survival analysis</topic><topic>Vascular endothelial growth factor</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sutedja, N A</creatorcontrib><creatorcontrib>van der Schouw, Y T</creatorcontrib><creatorcontrib>Fischer, K</creatorcontrib><creatorcontrib>Sizoo, E M</creatorcontrib><creatorcontrib>Huisman, M H B</creatorcontrib><creatorcontrib>Veldink, J H</creatorcontrib><creatorcontrib>Van den Berg, L H</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sutedja, N A</au><au>van der Schouw, Y T</au><au>Fischer, K</au><au>Sizoo, E M</au><au>Huisman, M H B</au><au>Veldink, J H</au><au>Van den Berg, L H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>82</volume><issue>6</issue><spage>638</spage><epage>642</epage><pages>638-642</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>ObjectivesReports of increased amyotrophic lateral sclerosis (ALS) with hyperlipidaemia and elevated plasma homocysteine levels as well as cigarette-smoking and polymorphisms in angiogenic genes suggest a role for altered vascular homeostasis in ALS pathogenesis. The authors assessed the association between vascular risk factors and ALS.MethodsTraditional cardiovascular risk factors (smoking, hypertension, hypercholesterolaemia, diabetes and body mass index (BMI)) and cardiovascular disease prior to ALS onset established by a questionnaire were compared in 334 patients and 538 age- and sex-matched controls. Biochemical assessments (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hs-CRP, and homocysteine) at diagnosis were measured in blood samples of 303 patients with ALS and compared with prospectively collected data from 2100 population-based controls.ResultsPatients with ALS used cholesterol-lowering agents less frequently (OR=0.6, p=0.008) and had a lower BMI (OR=0.9, p=0.001), a lower LDL/HDL ratio (women: OR=0.5, p<0.001; men: OR=0.4, p<0.001) and lower homocysteine levels (women: OR=0.9, p=0.02; men: OR=0.9, p<0.001). The mean LDL and TC levels were significantly lower among patients with a lower functional vital capacity percentage of predicted (FVC). In the univariate analysis, a higher LDL/HDL ratio correlated with increased survival (HR=0.9, p=0.04); after adjusting for the confounders age, site and FVC, no difference was observed.ConclusionsVascular risk factors, measured clinically and biochemically, were not associated with increased ALS. Instead, patients reported less use of cholesterol-lowering medication and had a lower premorbid BMI and favourable lipid profile—all findings consistent with the hypothesis that a higher metabolic rate plays a role in ALS.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd</pub><pmid>21471184</pmid><doi>10.1136/jnnp.2010.236752</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Aged Aged, 80 and over Alzheimer's disease Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - blood Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - mortality Angina pectoris Body Mass Index C-Reactive Protein - metabolism Cancer Cardiovascular Diseases - blood Cardiovascular Diseases - complications Cholesterol - blood Cohort analysis Female High density lipoprotein Homocysteine Homocysteine - blood Humans Hypotheses Lipids Male Middle Aged Motor neuron disease Patients Questionnaires Regression analysis Risk Factors Self Report Smoking - adverse effects Survival analysis Vascular endothelial growth factor Women |
| title | Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis |
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