The ins and outs of population relationships in west-Mediterranean islands: data from autosomal Alu polymorphisms and Alu/STR compound systems
The islands of the West Mediterranean have played a central role in numerous archaeological, historical and anthropological studies due to their active participation in the history of main Mediterranean civilisations. However, genetic data failed to fit in both their degree of internal differentiati...
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| Veröffentlicht in: | Journal of human genetics 2007-12, Vol.52 (12), p.999-1010 |
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| description | The islands of the West Mediterranean have played a central role in numerous archaeological, historical and anthropological studies due to their active participation in the history of main Mediterranean civilisations. However, genetic data failed to fit in both their degree of internal differentiation and relationships. A set of 18
Alu
markers and three short tandem repeats (STRs) closely linked to the CD4, F13B and DM
Alu
have been analysed in seven samples from Majorca, Corsica, Sardinia and Sicily to explore some of these issues. Our samples show a high genetic heterogeneity inside and among islands for the
Alu
data. Global differentiation among islands (F
ST
2.2%) is slightly higher than that described for Europeans and North Africans. Both the estimated divergence times among samples and the high population heterogeneity revealed by
Alu
data are compatible with population differences since the first islands’ settlement in the Paleolithic period. However, the high within-population diversities and the remarkable homogeneity observed in both STR and
Alu
/STR haplotype variation indicated that, at least since Neolithic times, gene flow has been acting in west Mediterranean. Genetic drift in west-coast Sardinia and gene flow in west Sicily have contributed to their general differentiation, whereas Corsica, Majorca and east Sicily seem to reflect more recent historical relationships from continental south Europe. |
| doi_str_mv | 10.1007/s10038-007-0206-6 |
| format | Article |
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Alu
markers and three short tandem repeats (STRs) closely linked to the CD4, F13B and DM
Alu
have been analysed in seven samples from Majorca, Corsica, Sardinia and Sicily to explore some of these issues. Our samples show a high genetic heterogeneity inside and among islands for the
Alu
data. Global differentiation among islands (F
ST
2.2%) is slightly higher than that described for Europeans and North Africans. Both the estimated divergence times among samples and the high population heterogeneity revealed by
Alu
data are compatible with population differences since the first islands’ settlement in the Paleolithic period. However, the high within-population diversities and the remarkable homogeneity observed in both STR and
Alu
/STR haplotype variation indicated that, at least since Neolithic times, gene flow has been acting in west Mediterranean. Genetic drift in west-coast Sardinia and gene flow in west Sicily have contributed to their general differentiation, whereas Corsica, Majorca and east Sicily seem to reflect more recent historical relationships from continental south Europe.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1007/s10038-007-0206-6</identifier><identifier>PMID: 17957332</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Alu Elements ; Biomedicine ; CD4 antigen ; Ethnic Groups ; Gene Expression ; Gene Flow ; Gene Frequency ; Gene Function ; Gene Therapy ; Genetic Drift ; Genetic Heterogeneity ; Genetics ; Haplotypes ; Human Genetics ; Humans ; Islands ; Life Sciences ; Mediterranean Islands ; Molecular Medicine ; Original Article ; Polymorphism, Genetic ; Population ; Population Groups ; Population Groups - ethnology ; Population Groups - genetics ; Populations and Evolution ; Short tandem repeats ; Tandem Repeat Sequences</subject><ispartof>Journal of human genetics, 2007-12, Vol.52 (12), p.999-1010</ispartof><rights>The Japan Society of Human Genetics and Springer 2007</rights><rights>The Japan Society of Human Genetics and Springer 2007.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-5a8c98280b2d6e58e384883b16be0730c4cbd55d7ecb5c801e94a57e2446c9e13</citedby><cites>FETCH-LOGICAL-c471t-5a8c98280b2d6e58e384883b16be0730c4cbd55d7ecb5c801e94a57e2446c9e13</cites><orcidid>0000-0003-4594-2686</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10038-007-0206-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10038-007-0206-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17957332$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00628441$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonzalez-Perez, E.</creatorcontrib><creatorcontrib>Moral, P.</creatorcontrib><creatorcontrib>Via, M.</creatorcontrib><creatorcontrib>Vona, G.</creatorcontrib><creatorcontrib>Varesi, L.</creatorcontrib><creatorcontrib>Santamaria, J.</creatorcontrib><creatorcontrib>Gaya-Vidal, M.</creatorcontrib><creatorcontrib>Esteban, E.</creatorcontrib><title>The ins and outs of population relationships in west-Mediterranean islands: data from autosomal Alu polymorphisms and Alu/STR compound systems</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><addtitle>J Hum Genet</addtitle><description>The islands of the West Mediterranean have played a central role in numerous archaeological, historical and anthropological studies due to their active participation in the history of main Mediterranean civilisations. However, genetic data failed to fit in both their degree of internal differentiation and relationships. A set of 18
Alu
markers and three short tandem repeats (STRs) closely linked to the CD4, F13B and DM
Alu
have been analysed in seven samples from Majorca, Corsica, Sardinia and Sicily to explore some of these issues. Our samples show a high genetic heterogeneity inside and among islands for the
Alu
data. Global differentiation among islands (F
ST
2.2%) is slightly higher than that described for Europeans and North Africans. Both the estimated divergence times among samples and the high population heterogeneity revealed by
Alu
data are compatible with population differences since the first islands’ settlement in the Paleolithic period. However, the high within-population diversities and the remarkable homogeneity observed in both STR and
Alu
/STR haplotype variation indicated that, at least since Neolithic times, gene flow has been acting in west Mediterranean. Genetic drift in west-coast Sardinia and gene flow in west Sicily have contributed to their general differentiation, whereas Corsica, Majorca and east Sicily seem to reflect more recent historical relationships from continental south Europe.</description><subject>Alu Elements</subject><subject>Biomedicine</subject><subject>CD4 antigen</subject><subject>Ethnic Groups</subject><subject>Gene Expression</subject><subject>Gene Flow</subject><subject>Gene Frequency</subject><subject>Gene Function</subject><subject>Gene Therapy</subject><subject>Genetic Drift</subject><subject>Genetic Heterogeneity</subject><subject>Genetics</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Islands</subject><subject>Life Sciences</subject><subject>Mediterranean Islands</subject><subject>Molecular Medicine</subject><subject>Original Article</subject><subject>Polymorphism, Genetic</subject><subject>Population</subject><subject>Population Groups</subject><subject>Population Groups - ethnology</subject><subject>Population Groups - genetics</subject><subject>Populations and Evolution</subject><subject>Short tandem repeats</subject><subject>Tandem Repeat Sequences</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kd2K1EAQhYMo7o8-gDfSIAhexO3_dLwbFt0VRgQdwbum06lxsqTTsStR5iV8ZjtmcEHwJjlUf3UOxSmKZ4y-ZpRWV5i_wpRZlpRTXeoHxTmTQpVc8K8P_2hZKqbZWXGBeEczzSv-uDhjVa0qIfh58Wt3ANINSNzQkjhPSOKejHGcezd1cSAJVoGHbsQMkp-AU_kB2m6ClNwAbiAd9nkb35DWTY7sUwzEzVPEGFxPNv2c_fpjiGk8dBjWpDy9-rz7RHwMY5zzAI84QcAnxaO96xGenv6XxZd3b3fXt-X2483768229LJiU6mc8bXhhja81aAMCCONEQ3TDdBKUC990yrVVuAb5Q1lUEunKuBSal8DE5fFq9X34Ho7pi64dLTRdfZ2s7XLjFLNjZTsx8K-XNkxxe9zPt-GDj30-WiIM1ptVI6ndQZf_APexTkN-Q7LJVeaSckXO7ZSPkXEBPu_-YzapVa71moXudRqdd55fnKemwDt_capxwzwFcD8NHyDdB_9f9ffzFGuNQ</recordid><startdate>20071201</startdate><enddate>20071201</enddate><creator>Gonzalez-Perez, E.</creator><creator>Moral, P.</creator><creator>Via, M.</creator><creator>Vona, G.</creator><creator>Varesi, L.</creator><creator>Santamaria, J.</creator><creator>Gaya-Vidal, M.</creator><creator>Esteban, E.</creator><general>Springer Japan</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-4594-2686</orcidid></search><sort><creationdate>20071201</creationdate><title>The ins and outs of population relationships in west-Mediterranean islands: data from autosomal Alu polymorphisms and Alu/STR compound systems</title><author>Gonzalez-Perez, E. ; 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However, genetic data failed to fit in both their degree of internal differentiation and relationships. A set of 18
Alu
markers and three short tandem repeats (STRs) closely linked to the CD4, F13B and DM
Alu
have been analysed in seven samples from Majorca, Corsica, Sardinia and Sicily to explore some of these issues. Our samples show a high genetic heterogeneity inside and among islands for the
Alu
data. Global differentiation among islands (F
ST
2.2%) is slightly higher than that described for Europeans and North Africans. Both the estimated divergence times among samples and the high population heterogeneity revealed by
Alu
data are compatible with population differences since the first islands’ settlement in the Paleolithic period. However, the high within-population diversities and the remarkable homogeneity observed in both STR and
Alu
/STR haplotype variation indicated that, at least since Neolithic times, gene flow has been acting in west Mediterranean. Genetic drift in west-coast Sardinia and gene flow in west Sicily have contributed to their general differentiation, whereas Corsica, Majorca and east Sicily seem to reflect more recent historical relationships from continental south Europe.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>17957332</pmid><doi>10.1007/s10038-007-0206-6</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4594-2686</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alu Elements Biomedicine CD4 antigen Ethnic Groups Gene Expression Gene Flow Gene Frequency Gene Function Gene Therapy Genetic Drift Genetic Heterogeneity Genetics Haplotypes Human Genetics Humans Islands Life Sciences Mediterranean Islands Molecular Medicine Original Article Polymorphism, Genetic Population Population Groups Population Groups - ethnology Population Groups - genetics Populations and Evolution Short tandem repeats Tandem Repeat Sequences |
| title | The ins and outs of population relationships in west-Mediterranean islands: data from autosomal Alu polymorphisms and Alu/STR compound systems |
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