New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease

Parkinson's disease (PD) is a common neurodegenerative movement disorder that affects increasing number of elderly in the world population. The disease is caused by a selective degeneration of dopaminergic neurons in the substantia nigra pars compacta with the molecular mechanism underlying thi...

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Veröffentlicht in:	Biochimica et biophysica acta 2010-11, Vol.1802 (11), p.935-941
Hauptverfasser:	Xie, Weilin, Wan, Oi Wan, Chung, Kenny K.K.
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics alpha-Synuclein - physiology Animals Autophagy lysosomal pathway Humans Mitochondria - metabolism Mitochondria - physiology Models, Biological Mutation Neurodegeneration Parkin Parkinson Disease - genetics Parkinson Disease - physiopathology PINK1 Protein Conformation Proteins - chemistry Proteins - genetics Proteins - physiology Ubiquitin proteasomal system Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - physiology
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