Hearing function and thresholds: a genome-wide association study in European isolated populations identifies new loci and pathways

BackgroundHearing is a complex trait, but until now only a few genes are known to contribute to variability of this process. In order to discover genes and pathways that underlie auditory function, a genome-wide association study was carried out within the International Consortium G-EAR.MethodsMeta-...

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Veröffentlicht in:	Journal of medical genetics 2011-06, Vol.48 (6), p.369-374
Hauptverfasser:	Girotto, Giorgia, Pirastu, Nicola, Sorice, Rossella, Biino, Ginevra, Campbell, Harry, d'Adamo, Adamo P, Hastie, Nicholas D, Nutile, Teresa, Polasek, Ozren, Portas, Laura, Rudan, Igor, Ulivi, Sheila, Zemunik, Tatijana, Wright, Alan F, Ciullo, Marina, Hayward, Caroline, Pirastu, Mario, Gasparini, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Auditory Threshold Biological and medical sciences Carrier Proteins - genetics Databases, Genetic Doublecortin-Like Kinases Ears & hearing Europe - epidemiology Female Founder Effect genetic epidemiology Genetic Linkage Genome-Wide Association Study - methods Genomes GWAS Hair Hearing - genetics Hearing loss Hearing Loss - ethnology Hearing Loss - genetics Hearing protection Homeostasis Humans Intracellular Signaling Peptides and Proteins - genetics isolated populations Male Medical sciences meta-analysis Mice Molecular basis of hearing system molecular genetics Otorhinolaryngology. Stomatology Phenotype Polymorphism, Single Nucleotide Protein Serine-Threonine Kinases - genetics Receptor-Like Protein Tyrosine Phosphatases, Class 2 - genetics Receptors, Metabotropic Glutamate - genetics Whites - genetics ‘in silico’ pathways
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Beschreibung
Zusammenfassung:	BackgroundHearing is a complex trait, but until now only a few genes are known to contribute to variability of this process. In order to discover genes and pathways that underlie auditory function, a genome-wide association study was carried out within the International Consortium G-EAR.MethodsMeta-analysis of genome-wide association study's data from six isolated populations of European ancestry for an overall number of 3417 individuals.ResultsEight suggestive significant loci (p
ISSN:	0022-2593 1468-6244
DOI:	10.1136/jmg.2010.088310