Rituximab-related late-onset neutropenia in a patient with severe rheumatoid arthritis

A 34-year-old white woman, with a 22-year history of refractory and destructive RA, had been treated with a long list of disease-modifying antirheumatic drugs (gold salts, thiopronine, d -penicillamine, sulfasalazine, azathioprine, ciclosporin, methotrexate (MTX) and etanercept). Rheumatoid factor w...

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Veröffentlicht in:Annals of the rheumatic diseases 2008-06, Vol.67 (6), p.893-894
Hauptverfasser: Marotte, H, Paintaud, G, Watier, H, Miossec, P
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container_end_page 894
container_issue 6
container_start_page 893
container_title Annals of the rheumatic diseases
container_volume 67
creator Marotte, H
Paintaud, G
Watier, H
Miossec, P
description A 34-year-old white woman, with a 22-year history of refractory and destructive RA, had been treated with a long list of disease-modifying antirheumatic drugs (gold salts, thiopronine, d -penicillamine, sulfasalazine, azathioprine, ciclosporin, methotrexate (MTX) and etanercept). Rheumatoid factor was positive and antinuclear and anti-DNA antibodies were negative. Because of persistent active disease (28 joint count Disease Activity Score 5.86) despite treatment with MTX (25 mg/week), etanercept (50 mg/week) and prednisone (10 mg/day), rituximab (two 1 g infusions at a 2-week interval) was started, combined with MTX and steroids in December 2005.
doi_str_mv 10.1136/ard.2007.081166
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Rheumatoid factor was positive and antinuclear and anti-DNA antibodies were negative. Because of persistent active disease (28 joint count Disease Activity Score 5.86) despite treatment with MTX (25 mg/week), etanercept (50 mg/week) and prednisone (10 mg/day), rituximab (two 1 g infusions at a 2-week interval) was started, combined with MTX and steroids in December 2005.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2007.081166</identifier><identifier>PMID: 18474658</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adult ; Antibodies, Monoclonal - adverse effects ; Antibodies, Monoclonal, Murine-Derived ; Antirheumatic Agents - adverse effects ; Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - immunology ; Biological and medical sciences ; Bone marrow ; Disease ; Diseases of the osteoarticular system ; Female ; Granulocytes ; Hematologic and hematopoietic diseases ; Humans ; Immunomodulators ; Inflammatory joint diseases ; Life Sciences ; Lymphoma ; Medical sciences ; Neutropenia ; Neutropenia - chemically induced ; Other diseases. Hematologic involvement in other diseases ; Pharmacology. 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Rheumatoid factor was positive and antinuclear and anti-DNA antibodies were negative. 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subjects Adult
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal, Murine-Derived
Antirheumatic Agents - adverse effects
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - immunology
Biological and medical sciences
Bone marrow
Disease
Diseases of the osteoarticular system
Female
Granulocytes
Hematologic and hematopoietic diseases
Humans
Immunomodulators
Inflammatory joint diseases
Life Sciences
Lymphoma
Medical sciences
Neutropenia
Neutropenia - chemically induced
Other diseases. Hematologic involvement in other diseases
Pharmacology. Drug treatments
Rheumatoid arthritis
Rituximab
Time
title Rituximab-related late-onset neutropenia in a patient with severe rheumatoid arthritis
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