Inhibition of SRY-Calmodulin Complex Formation Induces Ectopic Expression of Ovarian Cell Markers in Developing XY Gonads

The transcription factor sex-determining region of the Y chromosome (SRY) plays a key role in human sex determination, because mutations in SRY cause disorders of sex development in XY individuals. During gonadal development, Sry in pre-Sertoli cells activates Sox9 gene transcription, committing the...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-07, Vol.152 (7), p.2883-2893
Hauptverfasser:	Sim, Helena, Argentaro, Anthony, Czech, Daniel P, Bagheri-Fam, Stefan, Sinclair, Andrew H, Koopman, Peter, Boizet-Bonhoure, Brigitte, Poulat, Francis, Harley, Vincent R
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Animals Antigens, Differentiation - metabolism Biological and medical sciences Calcium-binding protein Calmodulin Calmodulin - antagonists & inhibitors Calmodulin - metabolism Calmodulin-Binding Proteins - genetics Calmodulin-Binding Proteins - metabolism Cell Nucleus - metabolism Cell Nucleus - ultrastructure Cercopithecus aethiops Complex formation COS Cells Differentiation Ectopic expression Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Fetuses Forkhead Box Protein L2 Forkhead protein Forkhead Transcription Factors - metabolism Fundamental and applied biological sciences. Psychology Genetics Gonads Imports Life Sciences Localization Male Mice Mutation Nuclear transport Organ Culture Techniques Ovaries Protein transport Recombinant Proteins - metabolism Sertoli cells Sex Sex determination Sex Determination Processes - drug effects Sex-Determining Region Y Protein - genetics Sex-Determining Region Y Protein - metabolism Sox9 protein SOX9 Transcription Factor - genetics SOX9 Transcription Factor - metabolism Spermatic Cord - drug effects Spermatogenesis Testes Testis - physiology Testis - ultrastructure Thrombospondins - metabolism Transcription factors Transcriptional Activation - drug effects Vertebrates: endocrinology Y chromosome Y chromosomes
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