Expression and genomic analyses of Camelus dromedarius T cell receptor delta (TRD) genes reveal a variable domain repertoire enlargement due to CDR3 diversification and somatic mutation

By a combination of rapid amplification of cDNA ends (RACE) and reverse transcription-polymerase chain reaction (RT-PCR) we identified three T cell receptor delta variable (TRDV) subgroups and five joining (TRDJ) genes expressed in spleen, tonsils and blood of Camelus dromedarius. We provide evidenc...

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Veröffentlicht in:	Molecular immunology 2011-07, Vol.48 (12), p.1384-1396
Hauptverfasser:	Antonacci, Rachele, Mineccia, Micaela, Lefranc, Marie-Paule, Ashmaoui, Hassan M.E., Lanave, Cecilia, Piccinni, Barbara, Pesole, Graziano, Hassanane, Mohamed S., Massari, Serafina, Ciccarese, Salvatrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Camelus - genetics Camelus - immunology Camelus dromedarius Complementarity Determining Regions - genetics Gene Rearrangement, delta-Chain T-Cell Antigen Receptor Genes, T-Cell Receptor gamma Genetics IMGT Life Sciences Molecular Sequence Data Palatine Tonsil - cytology Palatine Tonsil - immunology Phylogeny Point Mutation Protein Structure, Tertiary Receptors, Antigen, T-Cell, gamma-delta - chemistry Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Analysis, DNA Sequence Analysis, Protein Somatic mutation Spleen - cytology Spleen - immunology TRD genes
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