Biologic role of activated leukocyte cell adhesion molecule overexpression in breast cancer cell lines and clinical tumor tissue

The activated leukocyte cell adhesion molecule (ALCAM) is overexpressed in many mammary tumors, but controversial results about its role and prognostic impact in breast cancer have been reported. Therefore, we evaluated the biologic effects of ALCAM expression in two breast cancer cell lines and a l...

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Veröffentlicht in:	Breast cancer research and treatment 2011-09, Vol.129 (2), p.347-360
Hauptverfasser:	Hein, Sibyll, Müller, Volkmar, Köhler, Nadine, Wikman, Harriet, Krenkel, Sylke, Streichert, Thomas, Schweizer, Michaela, Riethdorf, Sabine, Assmann, Volker, Ihnen, Maike, Beck, Katrin, Issa, Rana, Jänicke, Fritz, Pantel, Klaus, Milde-Langosch, Karin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens, CD - genetics Antigens, CD - metabolism Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - blood supply Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer research Cancer therapies Carcinoma, Ductal, Breast - blood supply Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Cell Adhesion Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cell Line, Tumor Cell Movement Chi-Square Distribution Enzyme-Linked Immunosorbent Assay Female Fetal Proteins - genetics Fetal Proteins - metabolism Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Kaplan-Meier Estimate Keratin Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Neovascularization, Physiologic Oligonucleotide Array Sequence Analysis Oncology Preclinical Study Prognosis Proportional Hazards Models Retrospective Studies Risk Assessment Risk Factors Survival Rate Time Factors Tissue Array Analysis - methods Transfection Tumors Up-Regulation Vascular endothelial growth factor
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