Characterisation of invasive group B streptococci from adults in Denmark 1999 to 2004
The aim of this study was to characterise the group B streptococci (GBS) isolates causing severe invasive infections in patients >15 years of age in Denmark from 1999 to 2004. A total of 411 invasive GBS isolates were phenotypically characterised by the capsular polysaccharide (CPS) serotype and...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2010-09, Vol.29 (9), p.1071-1077 |
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| creator | Lambertsen, L Ekelund, K Skovsted, I. C Liboriussen, A Slotved, H.-C |
| description | The aim of this study was to characterise the group B streptococci (GBS) isolates causing severe invasive infections in patients >15 years of age in Denmark from 1999 to 2004. A total of 411 invasive GBS isolates were phenotypically characterised by the capsular polysaccharide (CPS) serotype and protein Cα, Cβ and R4. The incidence of invasive GBS disease ranged from 2.2 to 3.2 per 100,000 adults in the study period, being highest among adults over 65 years of age. Diabetes was observed in 15% of the cases, 12% had alcohol abuse and 7% had cancer. Of all isolates, 77% were CPS serotypes Ia, Ib, III or V. The surface proteins Cα or R4 were detected as the only protein in 57% of the GBS isolates. Cβ was detected in 12% of the isolates, but always in combination with either Cα or both Cα and R4. The incidence of invasive GBS infections continued to increase in Denmark from 1999 to 2004. In that period, the overall case fatality was 14%. The most prevalent CPS serotypes were serotypes III, Ia, V and Ib. The most prevalent surface protein was R4 when testing for R4, Cα and Cβ. There was no clear relation between the GBS phenotype and infections with fatal outcome. |
| doi_str_mv | 10.1007/s10096-010-0941-z |
| format | Article |
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C ; Liboriussen, A ; Slotved, H.-C</creator><creatorcontrib>Lambertsen, L ; Ekelund, K ; Skovsted, I. C ; Liboriussen, A ; Slotved, H.-C</creatorcontrib><description>The aim of this study was to characterise the group B streptococci (GBS) isolates causing severe invasive infections in patients >15 years of age in Denmark from 1999 to 2004. A total of 411 invasive GBS isolates were phenotypically characterised by the capsular polysaccharide (CPS) serotype and protein Cα, Cβ and R4. The incidence of invasive GBS disease ranged from 2.2 to 3.2 per 100,000 adults in the study period, being highest among adults over 65 years of age. Diabetes was observed in 15% of the cases, 12% had alcohol abuse and 7% had cancer. Of all isolates, 77% were CPS serotypes Ia, Ib, III or V. The surface proteins Cα or R4 were detected as the only protein in 57% of the GBS isolates. Cβ was detected in 12% of the isolates, but always in combination with either Cα or both Cα and R4. The incidence of invasive GBS infections continued to increase in Denmark from 1999 to 2004. In that period, the overall case fatality was 14%. The most prevalent CPS serotypes were serotypes III, Ia, V and Ib. The most prevalent surface protein was R4 when testing for R4, Cα and Cβ. There was no clear relation between the GBS phenotype and infections with fatal outcome.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-010-0941-z</identifier><identifier>PMID: 20676713</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Adolescent ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Denmark ; Diabetes ; Disease ; Fatalities ; Female ; Humans ; Incidence ; Infections ; Internal Medicine ; Laboratories ; Male ; Medical Microbiology ; Methods ; Middle Aged ; Patients ; Proteins ; Risk Factors ; Serotyping ; Streptococcal Infections - epidemiology ; Streptococcal Infections - microbiology ; Streptococcus agalactiae - classification ; Streptococcus agalactiae - isolation & purification ; Vaccines ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2010-09, Vol.29 (9), p.1071-1077</ispartof><rights>Springer-Verlag 2010</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-f1d0a4b470344d99b3e946c2fa4cb8e75be33a4784ca3bca0a22a3833c587a5e3</citedby><cites>FETCH-LOGICAL-c503t-f1d0a4b470344d99b3e946c2fa4cb8e75be33a4784ca3bca0a22a3833c587a5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-010-0941-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-010-0941-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20676713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00612788$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lambertsen, L</creatorcontrib><creatorcontrib>Ekelund, K</creatorcontrib><creatorcontrib>Skovsted, I. C</creatorcontrib><creatorcontrib>Liboriussen, A</creatorcontrib><creatorcontrib>Slotved, H.-C</creatorcontrib><title>Characterisation of invasive group B streptococci from adults in Denmark 1999 to 2004</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>The aim of this study was to characterise the group B streptococci (GBS) isolates causing severe invasive infections in patients >15 years of age in Denmark from 1999 to 2004. A total of 411 invasive GBS isolates were phenotypically characterised by the capsular polysaccharide (CPS) serotype and protein Cα, Cβ and R4. The incidence of invasive GBS disease ranged from 2.2 to 3.2 per 100,000 adults in the study period, being highest among adults over 65 years of age. Diabetes was observed in 15% of the cases, 12% had alcohol abuse and 7% had cancer. Of all isolates, 77% were CPS serotypes Ia, Ib, III or V. The surface proteins Cα or R4 were detected as the only protein in 57% of the GBS isolates. Cβ was detected in 12% of the isolates, but always in combination with either Cα or both Cα and R4. The incidence of invasive GBS infections continued to increase in Denmark from 1999 to 2004. In that period, the overall case fatality was 14%. The most prevalent CPS serotypes were serotypes III, Ia, V and Ib. The most prevalent surface protein was R4 when testing for R4, Cα and Cβ. There was no clear relation between the GBS phenotype and infections with fatal outcome.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Denmark</subject><subject>Diabetes</subject><subject>Disease</subject><subject>Fatalities</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Proteins</subject><subject>Risk Factors</subject><subject>Serotyping</subject><subject>Streptococcal Infections - epidemiology</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus agalactiae - classification</subject><subject>Streptococcus agalactiae - isolation & purification</subject><subject>Vaccines</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1vEzEQhi0EoqHwA7iAxQVxWBh7vGv72IaPIkXiADlbs4433ZKsg70bif56HG0pEge42JL9vDNjP4w9F_BWAOh3uay2qUBABVaJ6vYBWwiFdaVQ40O2AIuqslriGXuS8w2UjNH6MTuT0OhGC1yw9fKaEvkxpD7T2MeBx473w5Fyfwx8m-J04Jc8jykcxuij9z3vUtxz2ky7MReSvw_DntJ3Lqy1fIxcAqin7FFHuxye3e3nbP3xw7flVbX68unz8mJV-RpwrDqxAVKt0oBKbaxtMVjVeNmR8q0Jum4DIiltlCdsPQFJSWgQfW001QHP2Zu57jXt3CH1ZZCfLlLvri5W7nQG0AipjTmKwr6e2UOKP6aQR7fvsw-7HQ0hTtkZY8pnCmX-S2plrJJWqkK--ou8iVMaypML1GBjUNcFEjPkU8w5he5-UgHu5NHNHl3x6E4e3W3JvLgrPLX7sLlP_BZXADkDuVwN25D-dP5X1ZdzqKPoaFuUu_VXCQJBGG0QGvwFJ6Cusg</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Lambertsen, L</creator><creator>Ekelund, K</creator><creator>Skovsted, I. 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C</au><au>Liboriussen, A</au><au>Slotved, H.-C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterisation of invasive group B streptococci from adults in Denmark 1999 to 2004</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>29</volume><issue>9</issue><spage>1071</spage><epage>1077</epage><pages>1071-1077</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>The aim of this study was to characterise the group B streptococci (GBS) isolates causing severe invasive infections in patients >15 years of age in Denmark from 1999 to 2004. A total of 411 invasive GBS isolates were phenotypically characterised by the capsular polysaccharide (CPS) serotype and protein Cα, Cβ and R4. The incidence of invasive GBS disease ranged from 2.2 to 3.2 per 100,000 adults in the study period, being highest among adults over 65 years of age. Diabetes was observed in 15% of the cases, 12% had alcohol abuse and 7% had cancer. Of all isolates, 77% were CPS serotypes Ia, Ib, III or V. The surface proteins Cα or R4 were detected as the only protein in 57% of the GBS isolates. Cβ was detected in 12% of the isolates, but always in combination with either Cα or both Cα and R4. The incidence of invasive GBS infections continued to increase in Denmark from 1999 to 2004. In that period, the overall case fatality was 14%. The most prevalent CPS serotypes were serotypes III, Ia, V and Ib. The most prevalent surface protein was R4 when testing for R4, Cα and Cβ. There was no clear relation between the GBS phenotype and infections with fatal outcome.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>20676713</pmid><doi>10.1007/s10096-010-0941-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2010-09, Vol.29 (9), p.1071-1077 |
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| subjects | Adolescent Adult Age Age Factors Aged Aged, 80 and over Biomedical and Life Sciences Biomedicine Cancer Denmark Diabetes Disease Fatalities Female Humans Incidence Infections Internal Medicine Laboratories Male Medical Microbiology Methods Middle Aged Patients Proteins Risk Factors Serotyping Streptococcal Infections - epidemiology Streptococcal Infections - microbiology Streptococcus agalactiae - classification Streptococcus agalactiae - isolation & purification Vaccines Young Adult |
| title | Characterisation of invasive group B streptococci from adults in Denmark 1999 to 2004 |
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