Cranial meningiomas in 411 NF2 patients with proven gene mutations: Clear positional effect of mutations, but absence of female severity effect on age at onset

Background: Meningiomas have been reported to occur in approximately 50% of neurofibromatosis type 2 (NF2) patients. The NF2 gene is commonly biallelically inactivated in both schwannomas and meningiomas. The spectrum of NF2 mutations consists mainly of truncating (nonsense and frameshift) mutations...

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Veröffentlicht in:	Journal of medical genetics 2011-01, Vol.48 (4)
Hauptverfasser:	Smith, Miriam Jane, Higgs, Jenny E, Bowers, Naomi L, Halliday, Dorothy, Patterson, Joan, Gillespie, James, Huson, Susan M, Freeman, Simon R, Lloyd, Simon, Rutherford, Scott A, King, Andrew T, Wallace, Andrew J, Ramsden, Richard T, Evans, D. Gareth R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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