Exposure–response analysis of tigecycline in pharmacodynamic simulations using different size inocula of target bacteria

Abstract This study explored tigecycline exposure–bacterial responses in pharmacodynamic simulations (in vitro kinetic model) using different inocula. One meticillin-resistant vancomycin-heteroresistant Staphylococcus aureus , one Enterococcus faecium and one extended-spectrum β-lactamase-producing...

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Veröffentlicht in:	International journal of antimicrobial agents 2010-08, Vol.36 (2), p.137-144
Hauptverfasser:	Sevillano, D, Aguilar, L, Alou, L, Giménez, M.J, González, N, Torrico, M, Cafini, F, Garcia-Rey, C, Garcia-Escribano, N, Prieto, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial activity Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases beta-Lactamases - metabolism Biological and medical sciences Computer Simulation Dose-Response Relationship, Drug Enterococcus faecium Enterococcus faecium - drug effects Escherichia coli - drug effects Escherichia coli - enzymology Glycylcyclines Human bacterial diseases Humans Infectious Disease Infectious diseases Inoculum effect Medical sciences Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Minocycline - analogs & derivatives Minocycline - pharmacology Pharmacodynamics Pharmacology. Drug treatments Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Stem Cells
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