HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus
Oral Diseases (2011) 17, 309–313 Objectives: Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft‐versus‐host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin‐like receptor (KIR) genes encode a family of receptors express...
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| creator | Carrozzo, M Elia, A Mereu, V Dametto, E Fasano, ME Broccoletti, R Rendine, S Amoroso, A |
| description | Oral Diseases (2011) 17, 309–313
Objectives: Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft‐versus‐host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin‐like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression.
Methods: A total of 81 patients with OLP (36 HCV+ve and 45 HCV−ve) and 217 healthy controls (HCV−ve) were typed for the presence of eight KIR genes and of HLA‐Cw* alleles by polymerase chain reaction‐sequence specific primer.
Results: There were no significant differences in the frequency of the KIR genes and HLA‐C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV−ve OLP patients.
Conclusions: The present data suggest that OLP is not associated with particular KIR genes or with HLA‐Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP‐HCV+ve patients remains unclear and might warrant further researches. |
| doi_str_mv | 10.1111/j.1601-0825.2010.01742.x |
| format | Article |
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Objectives: Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft‐versus‐host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin‐like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression.
Methods: A total of 81 patients with OLP (36 HCV+ve and 45 HCV−ve) and 217 healthy controls (HCV−ve) were typed for the presence of eight KIR genes and of HLA‐Cw* alleles by polymerase chain reaction‐sequence specific primer.
Results: There were no significant differences in the frequency of the KIR genes and HLA‐C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV−ve OLP patients.
Conclusions: The present data suggest that OLP is not associated with particular KIR genes or with HLA‐Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP‐HCV+ve patients remains unclear and might warrant further researches.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/j.1601-0825.2010.01742.x</identifier><identifier>PMID: 20860769</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Case-Control Studies ; Data processing ; Dentistry ; Female ; Gene expression ; Gene frequency ; Gene Frequency - genetics ; Genotypes ; Graft-versus-host reaction ; Haplotypes - genetics ; Hepatitis ; hepatitis C ; Hepatitis C - immunology ; Hepatitis C virus ; Histocompatibility antigen HLA ; HLA-C Antigens - genetics ; Humans ; Infection ; Infections ; killer cell immunoglobulin-like receptor ; Killer cell immunoglobulin-like receptors ; Killer Cells, Natural - immunology ; KIR protein ; Lichen planus ; Lichen Planus, Oral - immunology ; Lymphocytes T ; Male ; Middle Aged ; oral lichen planus ; Potassium channels (inwardly-rectifying) ; Primers ; Receptors, KIR - genetics ; Receptors, KIR2DL2 - genetics ; T-Lymphocytes - immunology ; Transplants & implants ; virus</subject><ispartof>Oral diseases, 2011-04, Vol.17 (3), p.309-313</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2010 John Wiley & Sons A/S.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5502-9cfd037200148aa4ba27cc712e1d0b3a67ba4ae5a2b9ec7d9bb5e933ceaf07563</citedby><cites>FETCH-LOGICAL-c5502-9cfd037200148aa4ba27cc712e1d0b3a67ba4ae5a2b9ec7d9bb5e933ceaf07563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1601-0825.2010.01742.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1601-0825.2010.01742.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20860769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00599892$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Carrozzo, M</creatorcontrib><creatorcontrib>Elia, A</creatorcontrib><creatorcontrib>Mereu, V</creatorcontrib><creatorcontrib>Dametto, E</creatorcontrib><creatorcontrib>Fasano, ME</creatorcontrib><creatorcontrib>Broccoletti, R</creatorcontrib><creatorcontrib>Rendine, S</creatorcontrib><creatorcontrib>Amoroso, A</creatorcontrib><title>HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Oral Diseases (2011) 17, 309–313
Objectives: Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft‐versus‐host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin‐like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression.
Methods: A total of 81 patients with OLP (36 HCV+ve and 45 HCV−ve) and 217 healthy controls (HCV−ve) were typed for the presence of eight KIR genes and of HLA‐Cw* alleles by polymerase chain reaction‐sequence specific primer.
Results: There were no significant differences in the frequency of the KIR genes and HLA‐C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV−ve OLP patients.
Conclusions: The present data suggest that OLP is not associated with particular KIR genes or with HLA‐Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP‐HCV+ve patients remains unclear and might warrant further researches.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Data processing</subject><subject>Dentistry</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene frequency</subject><subject>Gene Frequency - genetics</subject><subject>Genotypes</subject><subject>Graft-versus-host reaction</subject><subject>Haplotypes - genetics</subject><subject>Hepatitis</subject><subject>hepatitis C</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C virus</subject><subject>Histocompatibility antigen HLA</subject><subject>HLA-C Antigens - genetics</subject><subject>Humans</subject><subject>Infection</subject><subject>Infections</subject><subject>killer cell immunoglobulin-like receptor</subject><subject>Killer cell immunoglobulin-like receptors</subject><subject>Killer Cells, Natural - immunology</subject><subject>KIR protein</subject><subject>Lichen planus</subject><subject>Lichen Planus, Oral - immunology</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Middle Aged</subject><subject>oral lichen planus</subject><subject>Potassium channels (inwardly-rectifying)</subject><subject>Primers</subject><subject>Receptors, KIR - genetics</subject><subject>Receptors, KIR2DL2 - genetics</subject><subject>T-Lymphocytes - immunology</subject><subject>Transplants & implants</subject><subject>virus</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhiMEoqXwF5AlDohDtv6M4wOH1S7tLqyohECLuFiOM2G9ZJM0Ttrdf4_TlBw41RePZ553PKM3ihDBMxLO5X5GEkxinFIxozhkMZGczo7PovOp8DzETPBYUPbzLHrl_R4HSjH6MjqjOE2wTNR5lK0283hx-WX9Df2Gqu5ODXjkKlS3pkSlszuoUFOaqveoMZ2DqhvKBdgO8gChqq7i6X3vuh3awQB2zqMFunNt719HLwpTenjzeF9EP64-fV-s4s3N9Xox38RWCExjZYscM0nDlDw1hmeGSmsloUBynDGTyMxwA8LQTIGVucoyAYoxC6bAUiTsIvow9t2ZUjetO5j2pGvj9Gq-0UMOY6FUqugdCez7kW3a-rYH3-mD8xbKsCnUvdepUoQTzp9AJowzRhIRyHf_kfu6b6uwsiaCCyIYe-iXjpRta-9bKKZRCdaDuXqvBw_14KEezNUP5upjkL59_KDPDpBPwn9uBuDjCNy7Ek5PbqxvlushCvp41DvfwXHSm_aPTiSTQm-_XuvPy-1Vwpa_9Jb9BSy3v-w</recordid><startdate>201104</startdate><enddate>201104</enddate><creator>Carrozzo, M</creator><creator>Elia, A</creator><creator>Mereu, V</creator><creator>Dametto, E</creator><creator>Fasano, ME</creator><creator>Broccoletti, R</creator><creator>Rendine, S</creator><creator>Amoroso, A</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>201104</creationdate><title>HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus</title><author>Carrozzo, M ; Elia, A ; Mereu, V ; Dametto, E ; Fasano, ME ; Broccoletti, R ; Rendine, S ; Amoroso, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5502-9cfd037200148aa4ba27cc712e1d0b3a67ba4ae5a2b9ec7d9bb5e933ceaf07563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Data processing</topic><topic>Dentistry</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene frequency</topic><topic>Gene Frequency - genetics</topic><topic>Genotypes</topic><topic>Graft-versus-host reaction</topic><topic>Haplotypes - genetics</topic><topic>Hepatitis</topic><topic>hepatitis C</topic><topic>Hepatitis C - immunology</topic><topic>Hepatitis C virus</topic><topic>Histocompatibility antigen HLA</topic><topic>HLA-C Antigens - genetics</topic><topic>Humans</topic><topic>Infection</topic><topic>Infections</topic><topic>killer cell immunoglobulin-like receptor</topic><topic>Killer cell immunoglobulin-like receptors</topic><topic>Killer Cells, Natural - immunology</topic><topic>KIR protein</topic><topic>Lichen planus</topic><topic>Lichen Planus, Oral - immunology</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Middle Aged</topic><topic>oral lichen planus</topic><topic>Potassium channels (inwardly-rectifying)</topic><topic>Primers</topic><topic>Receptors, KIR - genetics</topic><topic>Receptors, KIR2DL2 - genetics</topic><topic>T-Lymphocytes - immunology</topic><topic>Transplants & implants</topic><topic>virus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrozzo, M</creatorcontrib><creatorcontrib>Elia, A</creatorcontrib><creatorcontrib>Mereu, V</creatorcontrib><creatorcontrib>Dametto, E</creatorcontrib><creatorcontrib>Fasano, ME</creatorcontrib><creatorcontrib>Broccoletti, R</creatorcontrib><creatorcontrib>Rendine, S</creatorcontrib><creatorcontrib>Amoroso, A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrozzo, M</au><au>Elia, A</au><au>Mereu, V</au><au>Dametto, E</au><au>Fasano, ME</au><au>Broccoletti, R</au><au>Rendine, S</au><au>Amoroso, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2011-04</date><risdate>2011</risdate><volume>17</volume><issue>3</issue><spage>309</spage><epage>313</epage><pages>309-313</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Oral Diseases (2011) 17, 309–313
Objectives: Oral Lichen Planus (OLP) is associated with hepatitis C virus (HCV) infection and resembles graft‐versus‐host disease (GVHD) both clinically and histologically. The killer cell immunoglobulin‐like receptor (KIR) genes encode a family of receptors expressed on NK and T cells and are supposed to play a significant role in GVHD and HCV infection. The aim of this study was to analyze the association among OLP, HCV infection and variants in KIR gene expression.
Methods: A total of 81 patients with OLP (36 HCV+ve and 45 HCV−ve) and 217 healthy controls (HCV−ve) were typed for the presence of eight KIR genes and of HLA‐Cw* alleles by polymerase chain reaction‐sequence specific primer.
Results: There were no significant differences in the frequency of the KIR genes and HLA‐C1/C2 group alleles between cases and controls. We only found a significant difference in the frequency of the gene KIR2DL2 between HCV+ve and HCV−ve OLP patients.
Conclusions: The present data suggest that OLP is not associated with particular KIR genes or with HLA‐Cw* alleles in patients without HCV infection. Contrarily, the role of the genes in OLP‐HCV+ve patients remains unclear and might warrant further researches.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20860769</pmid><doi>10.1111/j.1601-0825.2010.01742.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Alleles Case-Control Studies Data processing Dentistry Female Gene expression Gene frequency Gene Frequency - genetics Genotypes Graft-versus-host reaction Haplotypes - genetics Hepatitis hepatitis C Hepatitis C - immunology Hepatitis C virus Histocompatibility antigen HLA HLA-C Antigens - genetics Humans Infection Infections killer cell immunoglobulin-like receptor Killer cell immunoglobulin-like receptors Killer Cells, Natural - immunology KIR protein Lichen planus Lichen Planus, Oral - immunology Lymphocytes T Male Middle Aged oral lichen planus Potassium channels (inwardly-rectifying) Primers Receptors, KIR - genetics Receptors, KIR2DL2 - genetics T-Lymphocytes - immunology Transplants & implants virus |
| title | HLA-C/KIR genotypes in oral lichen planus patients infected or non-infected with hepatitis C virus |
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