Influence of Mixed Chimerism on the Results of Allogeneic Bone Marrow Transplantation for Leukemia
Serial cytogenetic studies were performed on 60 leukemic recipients of HLA-matched bone marrow transplants (BMT) who were prepared by high doses of alkylating agents and fractionated total body irradiation (TBI). Forty-three patients were recipients of untreated BMT and 17 were recipients of T-deple...
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| Veröffentlicht in: | Blood 1991-12, Vol.78 (11), p.3103-3106 |
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| creator | Bertheas, M.F. Lafage, M. Levy, P. Blaise, D. Stoppa, A.M. Viens, P. Mannoni, P. Maraninchi, D. |
| description | Serial cytogenetic studies were performed on 60 leukemic recipients of HLA-matched bone marrow transplants (BMT) who were prepared by high doses of alkylating agents and fractionated total body irradiation (TBI). Forty-three patients were recipients of untreated BMT and 17 were recipients of T-depleted BMT. Donor or host mitoses were identified by examination of sex chromosomes in 54 patients or by evaluation of the polymorphism of other chromosomes after specific banding in six patients. Mixed lymphoid chimerism (MLC) was identified in 29 patients and full donor lymphoid chimerism (FDLC) in 29 patients. Complete donor hematopoiesis was recovered in most patients after 12 months, but two T-depleted patients had persistent host cells at 46 and 52 months after the graft. Acute graft-versus-host disease was significantly less frequent in patients with MLC, especially when more than 10% of residual lymphoid cells were detected. The probability of relapse and survival was identical in patients with MLC and FDLC, except in patients with chronic myeloid leukemia where MLC was significantly associated with an increased risk of relapse. |
| doi_str_mv | 10.1182/blood.V78.11.3103.3103 |
| format | Article |
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Forty-three patients were recipients of untreated BMT and 17 were recipients of T-depleted BMT. Donor or host mitoses were identified by examination of sex chromosomes in 54 patients or by evaluation of the polymorphism of other chromosomes after specific banding in six patients. Mixed lymphoid chimerism (MLC) was identified in 29 patients and full donor lymphoid chimerism (FDLC) in 29 patients. Complete donor hematopoiesis was recovered in most patients after 12 months, but two T-depleted patients had persistent host cells at 46 and 52 months after the graft. Acute graft-versus-host disease was significantly less frequent in patients with MLC, especially when more than 10% of residual lymphoid cells were detected. The probability of relapse and survival was identical in patients with MLC and FDLC, except in patients with chronic myeloid leukemia where MLC was significantly associated with an increased risk of relapse.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V78.11.3103.3103</identifier><identifier>PMID: 1954396</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Acute Disease ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone Marrow Transplantation ; Bone Marrow Transplantation - immunology ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Chimera ; Graft Survival ; Graft vs Host Disease ; Graft vs Host Disease - immunology ; Humans ; Leukemia ; Leukemia - surgery ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - surgery ; Life Sciences ; Lymphocyte Depletion ; Medical sciences ; Santé publique et épidémiologie ; T-Lymphocytes ; T-Lymphocytes - immunology ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Blood, 1991-12, Vol.78 (11), p.3103-3106</ispartof><rights>1991 American Society of Hematology</rights><rights>1992 INIST-CNRS</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-625d187a68eab2ae1df51eabd63fd1b493be8c3c0750c9120269bc1ff71417023</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5148449$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1954396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.sorbonne-universite.fr/hal-00597642$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bertheas, M.F.</creatorcontrib><creatorcontrib>Lafage, M.</creatorcontrib><creatorcontrib>Levy, P.</creatorcontrib><creatorcontrib>Blaise, D.</creatorcontrib><creatorcontrib>Stoppa, A.M.</creatorcontrib><creatorcontrib>Viens, P.</creatorcontrib><creatorcontrib>Mannoni, P.</creatorcontrib><creatorcontrib>Maraninchi, D.</creatorcontrib><title>Influence of Mixed Chimerism on the Results of Allogeneic Bone Marrow Transplantation for Leukemia</title><title>Blood</title><addtitle>Blood</addtitle><description>Serial cytogenetic studies were performed on 60 leukemic recipients of HLA-matched bone marrow transplants (BMT) who were prepared by high doses of alkylating agents and fractionated total body irradiation (TBI). Forty-three patients were recipients of untreated BMT and 17 were recipients of T-depleted BMT. Donor or host mitoses were identified by examination of sex chromosomes in 54 patients or by evaluation of the polymorphism of other chromosomes after specific banding in six patients. Mixed lymphoid chimerism (MLC) was identified in 29 patients and full donor lymphoid chimerism (FDLC) in 29 patients. Complete donor hematopoiesis was recovered in most patients after 12 months, but two T-depleted patients had persistent host cells at 46 and 52 months after the graft. Acute graft-versus-host disease was significantly less frequent in patients with MLC, especially when more than 10% of residual lymphoid cells were detected. The probability of relapse and survival was identical in patients with MLC and FDLC, except in patients with chronic myeloid leukemia where MLC was significantly associated with an increased risk of relapse.</description><subject>Acute Disease</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Bone Marrow Transplantation - immunology</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Chimera</subject><subject>Graft Survival</subject><subject>Graft vs Host Disease</subject><subject>Graft vs Host Disease - immunology</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemia - surgery</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive</subject><subject>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - surgery</subject><subject>Life Sciences</subject><subject>Lymphocyte Depletion</subject><subject>Medical sciences</subject><subject>Santé publique et épidémiologie</subject><subject>T-Lymphocytes</subject><subject>T-Lymphocytes - immunology</subject><subject>Transfusions. Complications. Transfusion reactions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Bone Marrow Transplantation - immunology</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Chimera</topic><topic>Graft Survival</topic><topic>Graft vs Host Disease</topic><topic>Graft vs Host Disease - immunology</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemia - surgery</topic><topic>Leukemia, Myelogenous, Chronic, BCR-ABL Positive</topic><topic>Leukemia, Myelogenous, Chronic, BCR-ABL Positive - surgery</topic><topic>Life Sciences</topic><topic>Lymphocyte Depletion</topic><topic>Medical sciences</topic><topic>Santé publique et épidémiologie</topic><topic>T-Lymphocytes</topic><topic>T-Lymphocytes - immunology</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bertheas, M.F.</creatorcontrib><creatorcontrib>Lafage, M.</creatorcontrib><creatorcontrib>Levy, P.</creatorcontrib><creatorcontrib>Blaise, D.</creatorcontrib><creatorcontrib>Stoppa, A.M.</creatorcontrib><creatorcontrib>Viens, P.</creatorcontrib><creatorcontrib>Mannoni, P.</creatorcontrib><creatorcontrib>Maraninchi, D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bertheas, M.F.</au><au>Lafage, M.</au><au>Levy, P.</au><au>Blaise, D.</au><au>Stoppa, A.M.</au><au>Viens, P.</au><au>Mannoni, P.</au><au>Maraninchi, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Mixed Chimerism on the Results of Allogeneic Bone Marrow Transplantation for Leukemia</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1991-12-01</date><risdate>1991</risdate><volume>78</volume><issue>11</issue><spage>3103</spage><epage>3106</epage><pages>3103-3106</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Serial cytogenetic studies were performed on 60 leukemic recipients of HLA-matched bone marrow transplants (BMT) who were prepared by high doses of alkylating agents and fractionated total body irradiation (TBI). Forty-three patients were recipients of untreated BMT and 17 were recipients of T-depleted BMT. Donor or host mitoses were identified by examination of sex chromosomes in 54 patients or by evaluation of the polymorphism of other chromosomes after specific banding in six patients. Mixed lymphoid chimerism (MLC) was identified in 29 patients and full donor lymphoid chimerism (FDLC) in 29 patients. Complete donor hematopoiesis was recovered in most patients after 12 months, but two T-depleted patients had persistent host cells at 46 and 52 months after the graft. Acute graft-versus-host disease was significantly less frequent in patients with MLC, especially when more than 10% of residual lymphoid cells were detected. The probability of relapse and survival was identical in patients with MLC and FDLC, except in patients with chronic myeloid leukemia where MLC was significantly associated with an increased risk of relapse.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>1954396</pmid><doi>10.1182/blood.V78.11.3103.3103</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Disease Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation Bone Marrow Transplantation - immunology Bone marrow, stem cells transplantation. Graft versus host reaction Chimera Graft Survival Graft vs Host Disease Graft vs Host Disease - immunology Humans Leukemia Leukemia - surgery Leukemia, Myelogenous, Chronic, BCR-ABL Positive Leukemia, Myelogenous, Chronic, BCR-ABL Positive - surgery Life Sciences Lymphocyte Depletion Medical sciences Santé publique et épidémiologie T-Lymphocytes T-Lymphocytes - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Influence of Mixed Chimerism on the Results of Allogeneic Bone Marrow Transplantation for Leukemia |
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