CHANGE IN OPTIC NERVE HEAD TOPOGRAPHY IN HEALTHY VOLUNTEERS. AN ELEVEN-YEAR FOLLOW-UP
Aim: To study longitudinal changes in optic nerve head (ONH) topography in healthy volunteers. Methods: One eye each of 36 healthy volunteers was prospectively followed for 11 (7-13) years with the Heidelberg Retina Tomograph I (HRT I). All eyes had normal visual fields, non-glaucomatous ONHs, no de...
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| Veröffentlicht in: | British journal of ophthalmology 2010-10, Vol.95 (6) |
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| container_title | British journal of ophthalmology |
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| creator | Harju, Mika Kurvinen, Leena Saari, Jukka Vesti, Eija |
| description | Aim: To study longitudinal changes in optic nerve head (ONH) topography in healthy volunteers. Methods: One eye each of 36 healthy volunteers was prospectively followed for 11 (7-13) years with the Heidelberg Retina Tomograph I (HRT I). All eyes had normal visual fields, non-glaucomatous ONHs, no defects on red-free nerve fibre layer photographs, and intraocular pressure (IOP) |
| doi_str_mv | 10.1136/bjo.2010.186213 |
| format | Article |
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AN ELEVEN-YEAR FOLLOW-UP</title><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Harju, Mika ; Kurvinen, Leena ; Saari, Jukka ; Vesti, Eija</creator><creatorcontrib>Harju, Mika ; Kurvinen, Leena ; Saari, Jukka ; Vesti, Eija</creatorcontrib><description>Aim: To study longitudinal changes in optic nerve head (ONH) topography in healthy volunteers. Methods: One eye each of 36 healthy volunteers was prospectively followed for 11 (7-13) years with the Heidelberg Retina Tomograph I (HRT I). All eyes had normal visual fields, non-glaucomatous ONHs, no defects on red-free nerve fibre layer photographs, and intraocular pressure (IOP) <22 mmHg. During the follow-up, no eye developed glaucoma; VFs remained normal, and no longitudinal changes appeared in nerve fibre layers assessed from red-free photographs or ONHs assessed from stereophotographs. The median baseline and follow-up IOPs were comparable (15 mmHg; range 10-20 mmHg, and 16 mmHg; 10-22mmHg, respectively; P=0.38). Images were re-evaluated with HRT III and ONHs graded as normal, borderline, or glaucomatous with the Moorfield's Regression Analysis (MRA). Results: Significant changes in HRT parameters indicating increased ONH cupping were detected in Cup Area (P=0.013), Cup-to Disc Area ratio (P=0.015), Rim Area (P=0.015), Mean Cup Depth (P=0.006), and Cup Shape Measure (P<0.001). With the MRA classification, nine eyes (9/31, 29%) had a change to the worse in the global or any of the sector classifications. Conclusion: Age-dependent changes occur in ONH topography detectable with the HRT.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.2010.186213</identifier><language>eng</language><publisher>BMJ Publishing Group</publisher><ispartof>British journal of ophthalmology, 2010-10, Vol.95 (6)</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttps://hal.science/hal-00595936$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Harju, Mika</creatorcontrib><creatorcontrib>Kurvinen, Leena</creatorcontrib><creatorcontrib>Saari, Jukka</creatorcontrib><creatorcontrib>Vesti, Eija</creatorcontrib><title>CHANGE IN OPTIC NERVE HEAD TOPOGRAPHY IN HEALTHY VOLUNTEERS. AN ELEVEN-YEAR FOLLOW-UP</title><title>British journal of ophthalmology</title><description>Aim: To study longitudinal changes in optic nerve head (ONH) topography in healthy volunteers. Methods: One eye each of 36 healthy volunteers was prospectively followed for 11 (7-13) years with the Heidelberg Retina Tomograph I (HRT I). All eyes had normal visual fields, non-glaucomatous ONHs, no defects on red-free nerve fibre layer photographs, and intraocular pressure (IOP) <22 mmHg. During the follow-up, no eye developed glaucoma; VFs remained normal, and no longitudinal changes appeared in nerve fibre layers assessed from red-free photographs or ONHs assessed from stereophotographs. The median baseline and follow-up IOPs were comparable (15 mmHg; range 10-20 mmHg, and 16 mmHg; 10-22mmHg, respectively; P=0.38). Images were re-evaluated with HRT III and ONHs graded as normal, borderline, or glaucomatous with the Moorfield's Regression Analysis (MRA). Results: Significant changes in HRT parameters indicating increased ONH cupping were detected in Cup Area (P=0.013), Cup-to Disc Area ratio (P=0.015), Rim Area (P=0.015), Mean Cup Depth (P=0.006), and Cup Shape Measure (P<0.001). With the MRA classification, nine eyes (9/31, 29%) had a change to the worse in the global or any of the sector classifications. Conclusion: Age-dependent changes occur in ONH topography detectable with the HRT.</description><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqVik2LwjAURYMoWD_WbrN1kZrXjmm7DJ2nKYSkdNKKq1Jhhqk4KBYG_Pe24B9wde859xKyAu4DhGJzOl_9gA8UiwDCEfHgQ8Qs4FEyJh7nPGIAAqZk1nXnHgMBkUfKVEmzR5oZanOXpdRgUSFVKD-ps7ndFzJXx2HulXZ9rawujUMsvnwqDUWNFRp2RFnQndXaHliZL8jkp7l038tXzsl6hy5V7Le51Ld7-9fcH_W1aWsldT04zrfJNgnFP4TvfJ_Z6kJp</recordid><startdate>20101022</startdate><enddate>20101022</enddate><creator>Harju, Mika</creator><creator>Kurvinen, Leena</creator><creator>Saari, Jukka</creator><creator>Vesti, Eija</creator><general>BMJ Publishing Group</general><scope>1XC</scope><scope>VOOES</scope></search><sort><creationdate>20101022</creationdate><title>CHANGE IN OPTIC NERVE HEAD TOPOGRAPHY IN HEALTHY VOLUNTEERS. AN ELEVEN-YEAR FOLLOW-UP</title><author>Harju, Mika ; Kurvinen, Leena ; Saari, Jukka ; Vesti, Eija</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-hal_primary_oai_HAL_hal_00595936v13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harju, Mika</creatorcontrib><creatorcontrib>Kurvinen, Leena</creatorcontrib><creatorcontrib>Saari, Jukka</creatorcontrib><creatorcontrib>Vesti, Eija</creatorcontrib><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harju, Mika</au><au>Kurvinen, Leena</au><au>Saari, Jukka</au><au>Vesti, Eija</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CHANGE IN OPTIC NERVE HEAD TOPOGRAPHY IN HEALTHY VOLUNTEERS. AN ELEVEN-YEAR FOLLOW-UP</atitle><jtitle>British journal of ophthalmology</jtitle><date>2010-10-22</date><risdate>2010</risdate><volume>95</volume><issue>6</issue><issn>0007-1161</issn><eissn>1468-2079</eissn><abstract>Aim: To study longitudinal changes in optic nerve head (ONH) topography in healthy volunteers. Methods: One eye each of 36 healthy volunteers was prospectively followed for 11 (7-13) years with the Heidelberg Retina Tomograph I (HRT I). All eyes had normal visual fields, non-glaucomatous ONHs, no defects on red-free nerve fibre layer photographs, and intraocular pressure (IOP) <22 mmHg. During the follow-up, no eye developed glaucoma; VFs remained normal, and no longitudinal changes appeared in nerve fibre layers assessed from red-free photographs or ONHs assessed from stereophotographs. The median baseline and follow-up IOPs were comparable (15 mmHg; range 10-20 mmHg, and 16 mmHg; 10-22mmHg, respectively; P=0.38). Images were re-evaluated with HRT III and ONHs graded as normal, borderline, or glaucomatous with the Moorfield's Regression Analysis (MRA). Results: Significant changes in HRT parameters indicating increased ONH cupping were detected in Cup Area (P=0.013), Cup-to Disc Area ratio (P=0.015), Rim Area (P=0.015), Mean Cup Depth (P=0.006), and Cup Shape Measure (P<0.001). With the MRA classification, nine eyes (9/31, 29%) had a change to the worse in the global or any of the sector classifications. Conclusion: Age-dependent changes occur in ONH topography detectable with the HRT.</abstract><pub>BMJ Publishing Group</pub><doi>10.1136/bjo.2010.186213</doi><oa>free_for_read</oa></addata></record> |
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| source | BMJ Journals - NESLi2; PubMed Central |
| title | CHANGE IN OPTIC NERVE HEAD TOPOGRAPHY IN HEALTHY VOLUNTEERS. AN ELEVEN-YEAR FOLLOW-UP |
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